Lactate emerges as both warning sign and driver of kidney injury after heart surgery
A new iScience study combining machine learning on over 6,500 patient records with rat and cell experiments shows that lactate ...
Tag: glycolysis
Newborns with congenital diaphragmatic hernia show hyperactive but inefficient mitochondria in endothelial cells
Endothelial cells from newborns with congenital diaphragmatic hernia display hyperactive but inefficient mitochondria, linking cellular energy dysfunction to pulmonary vascular ...
Scientists Uncover a Sugar-Burning Switch That Drives Liver Scarring
A new Nature Communications study shows that the ubiquitin ligase PRPF19 drives hepatic stellate cell activation and liver fibrosis by ...
How a Single Glycolytic Enzyme Decides Whether Cancer Cells Grow or Senesce
A new study in Advanced Science shows that losing the glycolytic enzyme TPI1 causes DHAP to accumulate and activates a ...
Sugar-Coated Selenium Nanoparticles Rewire Inflamed Joint Cells to Fight Osteoarthritis
Mannose-modified selenium nanoparticles target GLUT1-high inflammatory synovial cells in osteoarthritis, restoring selenoprotein antioxidant defenses, suppressing glycolysis, and easing pain and ...
Daphniphyllum-Derived Compound Starves Tumors of Energy to Block Their Self-Built Blood Vessels
Japanese researchers have shown that 22-benzyloxydaphlongaminone, a synthetic intermediate of the Daphniphyllum alkaloid isodaphlongamine H, blocks vasculogenic mimicry in lung ...
Long Noncoding RNA SNHG15 Rewires Liver Cancer Metabolism Through a PDK1-PDHE1α Phosphorylation Switch
A new study shows that the long noncoding RNA SNHG15 drives hepatocellular carcinoma progression by scaffolding the PGK1-PDK1-PDHE1α phosphorylation axis ...
Follicular Fluid Proteins Reveal Metabolic and Immune Clues in Ovarian Syndrome
Using 4D label-free proteomics, researchers identified 33 differentially expressed proteins in follicular fluid from patients with polyendocrine metabolic ovarian syndrome, ...
Sugar Metabolism Emerges as a Master Switch Controlling Bone Rebuilding
A new review argues that glycolysis acts as a signaling hub in bone remodeling, with glycolytic enzymes and metabolites such ...
Lingonberry Extract Starves Oral Cancer Cells by Rewiring Their Energy Metabolism
A cold-pressed lingonberry extract selectively inhibited the proliferation and invasion of oral cancer cells in laboratory experiments by disrupting the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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