Glycolysis enzymes emerge as central players in Alzheimer’s brain energy failure
A new review argues that dysregulated glycolytic and pyruvate-metabolizing enzymes in specific brain cell types form a central axis linking ...
Tag: glycolysis
Caloric Restriction Makes Colorectal Tumors More Vulnerable to Radiation in Mice
In a mouse and cell study, caloric restriction and fasting enhanced radiation's tumor-killing effects through the cGAS-STING pathway while protecting ...
Push or Block: Both Directions of PKM2 Activity Kill Leukemia Cells
A new study shows that both inhibiting and activating the metabolic enzyme PKM2 reduces nuclear accumulation of the protein, lowers ...
MDM4 stabilizes a glycolytic enzyme to fuel growth in TP53-mutant oral cancer
A new study reports that MDM4 promotes glycolysis and proliferation in TP53-mutant oral squamous cell carcinoma by stabilizing the enzyme ...
Blood-clotting protein’s cousin keeps stem cells resting and transplants thriving
A one-hour exposure to activated protein C keeps human blood stem cells quiescent and improves their short-term serial engraftment in ...
Traditional Chinese Formula Chuining Slows Pituitary Tumor Growth by Suppressing KIF20B
A new study shows that the traditional Chinese medicine formula Chuining inhibits pituitary tumor growth, promotes apoptosis, and suppresses glycolysis ...
Bone marrow stromal cells drive IL-6 metabolic rewiring and bortezomib resistance in multiple myeloma
Bone marrow stromal cells drive interleukin-6-mediated metabolic reprogramming and bortezomib resistance in multiple myeloma, a new open-access study reports.
Silencing HIF-1α Makes Erlotinib Work Better Against Lung Cancer Cells
A new cell-line study reports that silencing HIF-1α with siRNA synergizes with erlotinib to suppress proliferation, invasion and glycolysis in ...
AI Reads Bladder Cancer Slides and Pinpoints RTN3 Behind Chemotherapy Resistance
A multimodal AI model built from routine pathology slides predicts bladder cancer survival and led researchers to RTN3, which drives ...
PIK3CA mutation rewires immune and metabolic networks in cervical cancer cells
CRISPR-engineered cervical cancer cells carrying the PIK3CA-E545K mutation show coordinated immune signaling and metabolic rewiring, driven by suppressed lipid biosynthesis ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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