Proteolytic repair of DNA–protein crosslinks
A new review describes how cells remove bulky DNA–protein crosslinks through ubiquitylation-dependent proteolysis by the proteasome and the specialized protease ...
Tag: genome stability
Subtelomeric TelKO Elements Stabilize Short Telomeres in Telomerase-Lacking Yeast
A study of telomerase-deficient budding yeast shows that spreading subtelomeric TelKO elements to every chromosome end stabilizes uniformly shortened telomeres ...
Scientists Report First Chemical Probes That Block CDCA7’s DNA Recognition
Structure-guided screening has yielded two compounds that selectively interfere with CDCA7 binding to hemi-methylated DNA, partially recapitulating phenotypes of CDCA7 ...
Parasite Defies Textbook Genetics With Hundreds of Centromeres Scattered Across Its Chromosomes
Researchers report that the diarrheal parasite Cryptosporidium parvum carries hundreds of small centromere sites scattered across all eight chromosomes, providing ...
Bdelloid rotifers repair chromosomes across generations
A peer-reviewed study in the asexual bdelloid rotifer Adineta vaga shows how fragmented chromosomes can be retained across generations and ...
Cohesin reorganizes stressed DNA replication sites to protect genome stability
An experimental cell study finds that cohesin rapidly reorganizes stressed DNA replication sites and suppresses an error-prone restart pathway, helping ...
Review Reframes MAD Genes as a Coordinated Genome Stability Axis in Cancer
A Molecular Cancer review redefines the MAD gene family as a unified HORMA-domain genome surveillance system linking spindle checkpoint control ...
Cell studies link TONSL recognition of histone H3.1 to DNA repair
A University of Ottawa-led cell study found that TONSL recognizes chemical modifications on histone H3.1 to coordinate DNA repair and ...
DNA Methylation: The Dynamic Software of the Genome That Shapes Human Disease
A new collection of studies shows how the dynamic epigenetic mark of DNA methylation drives and predicts diseases from rheumatoid ...
Simulations reveal how yeast topoisomerase I may grip the transcription machinery
Computational modeling and 200-nanosecond simulations reveal a plausible, stable interaction interface between yeast topoisomerase I and the RNA polymerase III ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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