Simulations reveal how yeast topoisomerase I may grip the transcription machinery
Computational modeling and 200-nanosecond simulations reveal a plausible, stable interaction interface between yeast topoisomerase I and the RNA polymerase III ...
Tag: genome stability
DNA Repair Enzyme Pol ι Emerges as Key Player in Early Breast Cancer Risk in BRCA2 Carriers
A new iScience study shows that the error-prone polymerase Pol ι is induced in BRCA2-deficient mammary epithelial cells, where it ...
Antioxidant Enzyme Sod1 Revealed as a Master Guardian of Genome Stability
New whole-genome sequencing experiments in yeast reveal that the antioxidant enzyme Sod1 is a critical guardian of genomic integrity, whose ...
Genome’s Silent Guardian: HUSH Complex Emerges as Key Player in Cancer
A systematic review in Medical Oncology details how the HUSH complex silences retrotransposons through H3K9me3 deposition and how its dysregulation ...
How Well Can Your Cells Fix Broken DNA? A Landmark Review Maps the Tools That Measure Nucleotide Excision Repair
A new critical review in Molecular Biology Reports systematically compares the biochemical, cellular, and genome-wide assays used to measure nucleotide ...
DNA Repair Protein RAD54L Protects Developing Egg and Sperm Precursors from Toxic Enzyme Traps
New research in mice reveals that the DNA repair factor RAD54L protects primordial germ cells by stabilizing the E3 ligase ...
How Cells Choose Between DNA Repair Pathways—and Why It Matters for Cancer
A new review explains how the contest between BRCA1-BARD1 and the 53BP1 axis at DNA break ends determines whether cells ...
Loss of Checkpoint Kinase 2 Reshapes How Cells Repair Broken DNA
A new Cell Death & Discovery study shows that checkpoint kinase 2 deficiency alters how cells engage homologous recombination and ...
ATRX partners with 9-1-1 and CST to protect genome replication and telomeres
Every time a human cell divides, it must copy roughly six billion letters of DNA—a feat accomplished by molecular machines ...
Archaeal NurA Nuclease Structure Reveals Catalysis and Cooperation in DNA Break Repair
DNA double-strand breaks are among the most dangerous forms of genetic damage a cell can experience. When both strands of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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