Why siRNA Delivery Keeps Failing in Neurodegenerative Diseases
A new review argues that the bottleneck for RNAi therapies in Alzheimer's, Parkinson's and Huntington's disease is not gene silencing ...
Tag: gene silencing
Loop-ended dsRNA designs double stability and boost RNAi pesticide efficacy against Varroa mites
CSIRO and University of Sydney researchers report that loop-ended dsRNA designs with G-U wobble and asymmetric bulge modifications double dsRNA ...
DNA Methylation: The Dynamic Software of the Genome That Shapes Human Disease
A new collection of studies shows how the dynamic epigenetic mark of DNA methylation drives and predicts diseases from rheumatoid ...
Anionic Additive Helps Peptide Carriers Release siRNA and CRISPR Cargo Inside Cells
A study of arginine/tryptophan peptides shows that strong carrier-cargo binding blocks gene silencing, and adding a negatively charged component restores ...
Engineered Rhizobium Strain Opens Transient Gene Expression to Diverse Crops
An engineered Rhizobium rhizogenes strain called AS109 enables efficient transient gene expression across diverse dicot crop species, opening rapid functional ...
Handed-ness matters: right-handed chiral gold nanoparticles supercharge siRNA therapy against lung cancer
Intrinsically right-handed chiral gold nanoparticles with a multifaceted rhombi cuboctahedral shape deliver siRNA into lung cancer cells far more efficiently ...
Light, Hunger, and Humidity: The Genetic Switches That Launch a Deadly Crop Pathogen’s Spores
New research reveals how nitrogen starvation, a cryptochrome photoreceptor, and humidity checkpoints govern the transcriptional program that drives spore formation ...
Silencing a Fat-Making Master Switch Pushes Pancreatic Cancer Cells Toward Self-Destruction
New research links elevated SREBF1 expression to lipid metabolism signatures in pancreatic cancer and shows that silencing the gene triggers ...
Fungal enzyme RTT109 proves essential for inheriting silenced chromatin
A new study in Neurospora crassa shows that the replication-linked histone acetyltransferase RTT109, acting independently of its known product H3K56 ...
Silencing HPV16 Oncogenes E5 and E6 Emerges as a Promising Route Against Cervical Cancer
A new review in Virology Journal examines how siRNA and CRISPR/Cas gene-silencing technologies could target the HPV16 oncoproteins E5 and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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