New Patient Questionnaire Catches Ataxia Before Symptoms Show
A year-long Dutch study shows the PROM-Ataxia questionnaire validly captures disease burden in spinocerebellar ataxia, even in pre-ataxic mutation carriers, ...
Tag: gene silencing
Computers Take the Guesswork Out of Antisense Drug Design
A new review maps how computational tools, from RNA folding algorithms to molecular dynamics simulations, are transforming the design of ...
Gene Silencing of Complement C3 Shields Nerve-Muscle Junctions in Myasthenia Gravis Rats
Silencing hepatic C3 with GalNAc-targeted siRNA nearly eliminated plasma complement, preserved acetylcholine receptors, and reduced muscle weakness in a rat ...
Cholesterol-Tipped Gene Silencers Rescue Failing Neurons in Parkinson’s Mice
A new study shows that cholesterol-conjugated heteroduplex oligonucleotides can silence alpha-synuclein in the mouse brain, protecting dopaminergic neurons through the ...
RNAi Biopesticides Move From Lab Curiosity to Field Reality as First Products Win Registration
A Nature Plants review charts how the first registered RNAi-based biopesticides against the Colorado potato beetle and varroa mite signal ...
Mild Pepper Virus Turned Into a Powerful Gene Tool for Crop Scientists
Chinese researchers have engineered a new viral vector based on pepper mild mottle virus that enables rapid, high-efficiency gene expression ...
Fungal Weapon Hijacks Wheat Ethylene Signals to Blunt Crop Defenses
Scientists have discovered that the wheat pathogen Fusarium pseudograminearum uses a secreted effector protein called FpECIR to enter plant cells, ...
Small Viral C4 Protein Rewires Plant Cells and Triggers Severe Disease Symptoms
Researchers have provided the first experimental characterization of the C4 protein encoded by the recently described parsley yellow leaf curl ...
Three Drugs, One Disease: German Experts Issue First Consensus on Treating Cardiac Amyloidosis
A new expert consensus from the German Society of Amyloid Diseases and the German Cardiac Society provides the first practical ...
Cryo-EM Reveals How Polycomb Repressive Complex 1 Assembles, Works and Finds Its Targets
Ciapponi and colleagues have determined the cryo-EM structure of the canonical PRC1 holocomplex, revealing how its architecture coordinates assembly, H2A ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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