Heat-Stressed Fish Livers Rework Bile Acids to Survive Warming Seas
A seven-day heat stress experiment reveals how farmed golden pompano livers mobilize antioxidant defenses, suppress immunity, and remodel bile acid ...
Tag: FXR
Bile Acid Sensor FXR Drives Liver Regeneration by Rebuilding Its Immune Cell Army
New research shows that the bile acid receptor FXR coordinates monocyte recruitment and Kupffer cell proliferation through CCR2 and CSF1/PI3K/Akt ...
A Lipid Dial May Decide Whether Bile Duct Cancer Cells Live or Die by Ferroptosis
A new review proposes that the ratio of monounsaturated to polyunsaturated membrane phospholipids acts as a tunable rheostat controlling ferroptosis ...
Bile Acid Receptors FXR and TGR5 Emerge as Master Switches in Liver Disease
A comprehensive new review details how the bile acid receptors FXR and TGR5 regulate fat metabolism, inflammation, fibrosis, and liver ...
Selenium Shields the Liver: Trace Element Preserves Bile Pump and Blocks Cholestatic Damage in Rats
New research shows that selenium pretreatment at 1 mg/kg protects rats from chemically induced cholestatic liver injury by preserving BSEP ...
Common Bile Acid Drug Unlocks a Hidden Human Brake on Radiation-Driven Cancer Immunity
Researchers have identified a human-specific FXR-TRIM22-STAT1 checkpoint that suppresses radiation-induced antitumor immunity, and shown that the clinically approved bile acid ...
SMRT Corepressor Emerges as Master Regulator of Bile Acid Homeostasis Through Nuclear Receptor Control
A new review in Experimental & Molecular Medicine describes how the corepressor SMRT tunes nuclear receptor signaling to regulate bile ...
Bile Acids Emerge as Master Regulators Linking Gut Microbes, Immunity and Cancer
A new commentary in Holistic Integrative Oncology argues that bile acids act as master signaling molecules linking liver metabolism, gut ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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