How Lactate Rewrites Cell Fate: The Lactylation–Cell Death Axis That May Define Sepsis
A new review in the Journal of Advanced Research maps how sepsis-driven lactate accumulation chemically rewrites proteins through lactylation, tipping ...
Tag: ferroptosis
Iron overload disrupts bone homeostasis via dual pathways: inducing ferroptosis of preosteoblastic cells and shaping a proinflammatory immune milieu
Iron overload has long been recognized as an independent risk factor for osteoporosis, particularly in patients with hereditary hemochromatosis, thalassemia, ...
Tiny Pores or Total Rupture: How Lysosome Damage Decides Whether Cells Die by Apoptosis or Necrosis
A new review argues that lysosomal membrane permeabilization and lysosomal membrane rupture are mechanistically distinct failures that determine whether cells ...
Scientists Uncover Four Genes That May Explain Why Psoriasis and Depression Strike Together
An integrated multi-omics study identifies four shared genes and folic acid as a potential therapeutic link between psoriasis and depression.
Reactive oxygen species hold the key to repairing damaged peripheral nerves
A new review reveals how reactive oxygen species both drive and derail Schwann cell–mediated nerve repair, and how smart biomaterials ...
Two Cell Death Pathways May Converge to Drive Deadly Intestinal Disease in Preterm Infants
A new review argues that ferroptosis and pyroptosis may converge to drive necrotizing enterocolitis in preterm infants, and that biomarker-guided ...
Mapping Cancer’s Fatty Footprints: Spatial Lipidomics Enters the Clinic’s Waiting Room
A new review maps how spatial lipidomics is reshaping the study of ovarian, endometrial, and cervical cancers while warning that ...
Antimalarial drug mefloquine triggers ferroptosis in colorectal cancer, study finds
The concept of drug repurposing, sometimes called repositioning, has become an increasingly attractive strategy in oncology because established medicines already ...
Three overlooked amino acid transporters emerge as promising anti-cancer targets
A new review highlights the System N amino acid transporters SLC38A3, SLC38A5 and SLC38A7 as emerging metabolic vulnerabilities in cancer, ...
The Aging Kidney Gets a Data-Driven Atlas: Machine Learning and Ferroptosis Lead a New Research Era
A sweeping bibliometric analysis of 2,191 papers reveals that kidney aging research has exploded since 2018, with machine learning, ferroptosis, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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