Chemical Maps Expose Iron-Linked Enzyme as Hidden Guardian of Damaged DNA
A comprehensive chemogenomic map of the DNA damage response reveals that peroxiredoxin 1 safeguards cells against iron-driven oxidative DNA damage.
Tag: ferroptosis
Iron-Linked Cell Death May Explain Why Autism Risk Hits Male Mice Harder
A new mouse study links prenatal valproic acid exposure to ferroptosis-related brain damage that is more severe in males and ...
Desert Plant Compound Shows Promise Against Depression by Protecting the Gut
Total glycosides from Cistanche tubulosa relieved depressive-like behaviors and gut dysfunction in stressed mice by suppressing intestinal ACSL4-mediated ferroptosis through ...
Too Much Cysteine Comes at a Cost: Surplus Amino Acid Triggers Deadly Iron Overload in Cells
A new Nature Metabolism study shows that excess free cysteine disrupts mitochondrial iron homeostasis and triggers a distinct iron-dependent cell ...
Hidden Mitochondrial Transporters May Expose New Vulnerabilities in Colorectal Cancer
A new review highlights how three mitochondrial metabolite transporters are deregulated in colorectal cancer and jointly shape tumor metabolism, epigenetic ...
Copper and Iron Cell Death Pathways Offer a New Two-Front Attack on Liver Cancer
A new review in Medical Oncology argues that simultaneously targeting copper-triggered cuproptosis and iron-dependent ferroptosis could open a powerful two-front ...
Oxygenaging: How the Body’s Oxygen Cascade Shapes the Biology of Growing Old
A new Aging Cell review proposes Oxygenaging, a framework tracing how age-related breakdown across the oxygen cascade — from lungs ...
Nanomedicines Offer New Routes Past the Brain’s Defenses Against Drug-Resistant Tumours
A new review in Molecular Cancer details how five classes of nanomaterials could breach the blood–brain barrier and dismantle the ...
Lipid Metabolism Emerges as a Central Driver of Drug Resistance in Aggressive Lymphoma
A new review argues that lipid metabolic reprogramming acts as a convergence node for treatment resistance in aggressive non-Hodgkin lymphoma, ...
Engineered Exosomes Loaded With RNA Motifs and Boosted by Rab4 Aim to Trigger Ferroptosis in Endometrial Cancer
Scientists have engineered exosomes that use natural RNA-sorting motifs and Rab4-boosted production to deliver ferroptosis-inducing shRNAs directly to endometrial tumors.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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