Old Antibiotics, New Trick: Doxycycline Blocks Prostate Cancer Spread to Bone
Researchers report that the FDA-approved antibiotics doxycycline and methacycline selectively bind acetylated KLF5 and suppress prostate cancer bone metastasis by ...
Tag: epithelial-mesenchymal transition
Chaperonin Protein CCT2 Emerges as Key Driver of Aggressive Head and Neck Cancer and Cisplatin Resistance
New research shows that the chaperonin subunit CCT2 stabilizes the oncoprotein c-Myc to drive head and neck squamous cell carcinoma ...
Aging Fibroblasts Fuel Ovarian Cancer Growth Through a Single Secreted Protein
New research shows that senescent cancer-associated fibroblasts in high-grade serous ovarian cancer secrete Tenascin-C, which activates SDC4-ERK signaling in tumor ...
Collagen Scaffold in Tumors Primes Colorectal Cancer Cells to Evade Chemotherapy
Patient-derived organoid and xenograft models reveal that a collagen I-rich tumor matrix activates TGFβ signaling and LTBP2 expression, priming colorectal ...
One MicroRNA, Two Missions: Duplex From Pre-miR-16 Strikes Both VEGF and Hypoxia Pathways in Lung Cancer
A new Cell Death Discovery study shows that the two strands of the pre-miR-16-1 microRNA duplex can cooperatively suppress both ...
The Hidden Switch That Helps Breast Cancer Survive and Resist Treatment
A comprehensive new review maps how NF-κB signalling drives breast cancer progression, subtype-specific therapy resistance and tumour-microenvironment crosstalk, and argues ...
Old Antipsychotic Meets Mitochondrial Blocker in Two-Drug Strike on Cancer Cells
New research shows that pairing the decades-old antipsychotic chlorpromazine with the mitochondrial fission inhibitor mdivi-1 sharply boosts cancer cell death ...
Mathematicians Map Which Cellular States a Gene Network Can Truly Sustain
A new mathematical framework ranks which stable cellular states and multistable switches are most prevalent across all monotone Boolean models ...
Snail2 Emerges as the Master Switch Behind Partial EMT, Metastasis and Development
A comprehensive review in Cell Death Discovery maps how the transcription factor Snail2 governs partial epithelial-mesenchymal transition, driving both embryonic ...
Gut Microbes Emerge as Hidden Drivers of Diabetes and Pancreatic Cancer
A new review in Medical Oncology argues that gut microbial dysbiosis drives systemic inflammation that contributes to both type 2 ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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