Old Macrophage Secretomes Outperform Young Ones in Protecting Stressed Kidney Cells
In a mouse cell-culture study, macrophage donor age rather than the age of circulating extracellular vesicles determined how well hypoxia-stressed ...
Tag: epithelial-mesenchymal transition
Long Noncoding RNA KCNMB2-AS1 Drives Clear Cell Renal Cell Carcinoma Growth
Researchers report that the long noncoding RNA KCNMB2-AS1, activated by the transcription factor FOXP3, promotes clear cell renal cell carcinoma ...
Tumor Cells Build Their Own Blood Vessels in Colorectal Cancer, Review Finds
A new review in Cell Division details how colorectal cancer cells form their own blood-supply channels through vasculogenic mimicry, a ...
Tumor cells may revert to stem-like states, review argues
A new review proposes that mature tumor cells can dedifferentiate into cancer stem cells, acting as a non-genetic engine of ...
Obesity-linked leptin drives DNA hypomethylation in breast epithelial cells
A new study links obesity-associated leptin levels to global DNA hypomethylation and altered EMT gene expression in breast epithelial cells, ...
Blood protein CXCL2 shows strong accuracy detecting endometrial cancer before surgery
A prospective case-control study found preoperative serum CXCL2 discriminated endometrial cancer from benign gynecologic disease with an AUC of 0.923, ...
Enzyme PLA2G4A fuels lung cancer growth through an HSF1 signaling axis
A new study reports that the enzyme PLA2G4A promotes non-small cell lung cancer proliferation, survival and metastasis through an SP1–IL-1β–MAPK–HSF1 ...
Bladder Cancer Gene Signature Holds Up Across Two Large Cohorts
A reanalysis of two independent bladder cancer cohorts found 4,102 genes with concordant tumor-associated expression changes and confirmed five candidates ...
Cancer cells on the move shed giant vesicles packed with whole genomes
Migrating cancer cells shed large vesicles called MoVes that carry whole genomic DNA, organelles and EMT-linked proteins, according to a ...
Plant-Derived Nanoparticles Restore Tumor-Suppressor miR-34a to Block NOTCH1 in Triple-Negative Breast Cancer
Folate-functionalized chitosan nanoparticles carrying an Ailanthus excelsa stembark extract restored miR-34a and suppressed NOTCH1 signaling, reducing tumor growth, metastasis and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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