Early NOTCH1 Mutation Shields Esophageal Tissue from Turning Cancerous
A new evolutionary analysis shows that NOTCH1 mutations flourish in normal esophageal tissue but epistatically suppress the later driver mutations, ...
Tag: epistasis
Two Genes Team Up to Paint Barley Leaves in White and Green
German researchers have shown that white-striped leaves in an EMS-mutagenized barley line arise only when recessive mutations at two epistatic ...
Wild Relatives Hold the Genetic Keys to Future-Proof Crops, Review Finds
A new review argues that crop wild relatives hold vast untapped genetic diversity, but translating it into better cultivars requires ...
Scientists Map the Genes That Decide How Much Protein Sits in Every Maize Kernel
A new BMC Genomics study using three doubled-haploid populations identifies 14 QTLs, a chromosome 7 cluster and seven candidate genes ...
DNA Repair Enzymes RecA and UvrD Emerge as Central Players in Antibiotic Persister Survival
New genetic analysis in Escherichia coli reveals that the DNA repair hub proteins RecA and UvrD are essential for fluoroquinolone ...
Why One Antibody Rules Them All: Epistasis Blocks Broad Flu Protection
Deep mutational scanning of the CR9114 antibody reveals that epistasis and pleiotropy make cross-reactive breadth against both influenza A and ...
Non-linear kernels boost soybean genomic prediction while keeping the math breeders trust
A new study shows that non-linear kernel methods consistently match or outperform the standard linear model for predicting soybean yield, ...
Genomics Reshapes the Study of Antibiotic Tolerance and Treatment Failure
A Genome Biology review argues that genome-wide analyses, laboratory evolution and functional screens are revealing the genetic basis of antibiotic ...
AI Reads the Genome Like Language to Uncover Hidden Gene Interactions
A new deep learning framework called Epiformer combines the Evo 2 genome language model with a dual-channel network to detect ...
AI Language Model Rescues Human Drug Transporter Mutations a Computer Deemed Impossible
Researchers used a protein language model and an epistatic rescue algorithm to computationally humanize a bacterial peptide transporter, paving the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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