AI Decodes the Hidden Grammar of the Genome’s Master Organizer CTCF
A new computational framework called DeCTCF uses AI-predicted epigenomic features to sort more than 236,000 CTCF binding sites into 20 ...
Tag: epigenomics
Ancient DNA Reorganization May Explain How Octopuses Grew Such Complex Brains
A University of Vienna study finds that an ancient burst of genome reorganization created 3D DNA interactions, or regulatory entanglement, ...
Childhood Brain Tumor Study Uncovers KDM2B as a Selective Epigenetic Vulnerability
A comprehensive epigenomic map of medulloblastoma reveals that the chromatin regulator KDM2B sustains the highest-risk tumor subgroups by locking neuronal ...
Single-Cell Map of Gut Chromatin Reveals Which Cells Drive Crohn’s Disease Risk
A single-cell chromatin accessibility atlas of the human intestine maps regulatory programs across 29 cell types and shows that Crohn's ...
Hidden Aggression: Machine Learning Exposes Dangerous Biology in Low-Risk Prostate Cancer
Researchers at KTH Royal Institute of Technology used multi-omics analysis and machine learning to uncover molecular features linked to aggressive ...
DNA Methylation Episignatures Emerge as a Powerful New Diagnostic Layer for Rare Disease
A new review explains how DNA methylation episignatures provide functional evidence of disease mechanism in rare genetic disorders, helping resolve ...
Deep Learning Tool Reads Leukemia’s Regulatory Code to Predict Patient Risk
A new deep learning framework called TERfinder integrates multi-omics data to map enhancer-promoter interactions in myeloid leukemia, pinpointing key regulatory ...
Pig DNA Methylation Map Reveals Hidden Genetic Switches Behind Meat Traits
A massive multi-omics atlas of pig skeletal muscle shows how genetically regulated DNA methylation links sequence variation to gene expression ...
Hidden Flaws in a Leading DNA Methylation Chip Could Skew Studies of Diverse Populations
A comprehensive audit of the Illumina EPIC methylation array reveals tens of thousands of probes with cross-hybridization, misannotation, or population-specific ...
Spatial Multi-Omics Needs Reproducibility Standards Before It Can Reach the Clinic
A new review argues that spatial multi-omics must overcome reproducibility and standardization gaps before the technology can deliver on precision ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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