Walnut Compound Juglone Blocks Key Drug-Metabolizing Enzyme CYP2C9 in Lab Study
In vitro experiments show juglone, a naphthoquinone from walnut green husks, potently and competitively inhibits the human drug-metabolizing enzyme CYP2C9, ...
Tag: enzyme kinetics
Living Fossil Fungus Hides an Ancient Betalain Enzyme
A living fossil fungus carries a fully functional betalain-forming enzyme despite producing no betalains, expanding the evolutionary origins of the ...
How Seven Tiny Mutations Break a Metabolic Enzyme and Cause a Rare Brain and Heart Syndrome
New crystal structures and biochemical analyses reveal that seven disease-causing SHMT2 mutations sabotage the same mitochondrial enzyme through strikingly different ...
Music With Fast Tempo, Irregular Rhythm and Atonal Harmony Cuts Toxic Drug Metabolite in Rat Livers
Researchers found that fast-tempo, irregular-rhythm, atonal-harmony music reduced formation of the toxic acyl glucuronide of mycophenolic acid in rat liver ...
Hot Spring Enzyme From Türkiye Survives Boiling Temperatures and Harsh Solvents
Researchers at Atatürk University have purified a heat-loving, solvent-tolerant alpha-amylase from Bacillus licheniformis isolated in Türkiye's geothermal springs, achieving 71-fold ...
Sugar Molecules, Not Size, Keep Key Metabolic Enzyme Working Under Stress
A new study shows that sugar-based chemical interactions, rather than molecular crowding size, help the glycolytic enzyme PFKP stay active ...
Soil Bacterium Yields a Surprisingly Powerful Enzyme for Breaking Down PET Plastic Intermediates
A carboxylesterase from Bacillus halotolerans outperforms known enzymes at converting the PET breakdown products BHET and MHET into terephthalic acid, ...
Scientists Pin Down the Three Amino Acids That Power a Coral Tree Seed Enzyme
Chemical modification, fluorescence, and structural studies have identified one carboxylate, one tryptophan, and one serine residue as the essential catalytic ...
Bacterial Enzyme Serratiopeptidase Shows Promise Against Deadly Biofilms
Researchers purified serratiopeptidase from Serratia marcescens SP6 and showed the enzyme can inhibit biofilms of Pseudomonas aeruginosa and Staphylococcus aureus, ...
Scientists Uncover the Enzyme Behind the Sweet Scent of Plum Blossoms
Researchers have identified the enzyme PmCAAT1 as the specific catalyst that produces cinnamyl acetate, the signature aroma compound of Prunus ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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