Obesity from the perspective of the liver
A new review argues that obesity can be understood as a disorder of hepatic glucose and NADPH handling, in which ...
Tag: endoplasmic reticulum
Calcium and ROS: The Organelle-Level Dialogue That Decides the Fate of Insulin-Secreting Cells
A comprehensive review reveals how organelle-specific crosstalk between calcium and reactive oxygen species signaling governs insulin secretion and drives beta-cell ...
Inside the Cell’s Metal Highway: How Zinc, Manganese, and Iron Reach the ER and Golgi
A new review maps how zinc, manganese, and iron are transported into the ER and Golgi apparatus, revealing transporter families ...
Human Antibody Factories Reveal a Hidden Scaffold Named Caveolin-1β
Single-cell transcriptomics and proteomics have revealed that human plasma cells selectively express a non-caveolar Caveolin-1β isoform induced by XBP1, positioning ...
Cell’s Insert and Undo Machines Caught Working Together in One ER Supercomplex
Cryo-EM structures reveal that the ER membrane protein complex and the Spf1 ATPase form a conserved supercomplex that juxtaposes membrane ...
Yeast Cell Model Shows Cell Geometry Reshapes Gene Network Predictions
A spatially resolved model of the yeast galactose switch shows that intracellular architecture, especially ER-bound translation, changes gene regulation predictions.
Calcium Gatekeepers: TMBIM Proteins Steer Early Brain Development
New research shows that TMBIM family proteins regulate early neuronal differentiation by maintaining ER calcium stores that power SOCE, lysosomal ...
Lipid Nanoparticles Trigger Pain Receptor TRPA1 and Reshape Calcium Signaling in Cells
New research shows that synthetic lipid nanoparticles trigger irregular calcium signals in cells partly through the pain-sensing ion channel TRPA1, ...
How the cell builds its membrane proteins: new view of the EMC-bound translocon
Combining ribosome profiling, cryo-electron tomography and photocrosslinking, researchers have revealed how the ER membrane protein complex is recruited to the ...
Cellular Contact Points Called MAMs Emerge as Central Players in Heart Attack Damage
A new review in the Journal of Translational Medicine argues that mitochondria-associated endoplasmic reticulum membranes integrate lipid metabolism and ferroptosis ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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