Yeast Cell Model Shows Cell Geometry Reshapes Gene Network Predictions
A spatially resolved model of the yeast galactose switch shows that intracellular architecture, especially ER-bound translation, changes gene regulation predictions.
Tag: endoplasmic reticulum
Calcium Gatekeepers: TMBIM Proteins Steer Early Brain Development
New research shows that TMBIM family proteins regulate early neuronal differentiation by maintaining ER calcium stores that power SOCE, lysosomal ...
Lipid Nanoparticles Trigger Pain Receptor TRPA1 and Reshape Calcium Signaling in Cells
New research shows that synthetic lipid nanoparticles trigger irregular calcium signals in cells partly through the pain-sensing ion channel TRPA1, ...
How the cell builds its membrane proteins: new view of the EMC-bound translocon
Combining ribosome profiling, cryo-electron tomography and photocrosslinking, researchers have revealed how the ER membrane protein complex is recruited to the ...
Cellular Contact Points Called MAMs Emerge as Central Players in Heart Attack Damage
A new review in the Journal of Translational Medicine argues that mitochondria-associated endoplasmic reticulum membranes integrate lipid metabolism and ferroptosis ...
One Gene Swap Gives Peas Powerful New Defense Against Devastating Fusarium Wilt
Researchers have identified PsFwC9, a single dominant pea gene whose one amino acid change confers strong resistance to Fusarium wilt ...
Neurons Use a MicroRNA Factory on the ER to Decide Which Genetic Messages Ride Extracellular Vesicles
New research shows that the TRBP-containing microRNA production complex on the endoplasmic reticulum acts as a sorting hub that loads ...
Parasite Kinase on the Endoplasmic Reticulum Revealed as a Master Switch for Calcium, Motility and Virulence
A new study identifies the endoplasmic reticulum-localized kinase NcDYRK2 as a key regulator of calcium signaling, gliding motility, developmental gene ...
Scientists Discover the Gene Switch That Makes Alfalfa Flower Early
Researchers have identified 23 FTIP genes in alfalfa and shown that MsFTIP1 interacts directly with the florigen protein MsFT to ...
Fission Yeast Study Reveals How Gdt1, Gdt2 and Pmr1 Team Up to Balance Calcium and Manganese
New research shows that the fission yeast proteins Gdt1, Gdt2 and Pmr1 act in complementary pathways to regulate calcium and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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