TALK Potassium Channels Emerge as Hidden Regulators of Insulin Secretion
A new review links the TALK-1 and TALK-2 potassium channels to β-cell calcium handling and insulin secretion while cautioning that ...
Tag: endoplasmic reticulum
SEL1L emerges as a molecular gatekeeper of cellular protein quality control
A systematic review links the SEL1L-HRD1 quality control complex to neurodegeneration, cancer, metabolism and immunity.
Cell study reveals TRAP complex as a shared coronavirus dependency in the ER
A genome-wide CRISPR screen in cells identifies the ER translocon-associated protein complex, particularly TRAPγ, as a host factor coronaviruses exploit ...
Novel PGAP1 Splice-Site Variant Broadens Known Spectrum of GPI-Anchor Disorders
Researchers identified a novel homozygous PGAP1 splice-site variant, classified as likely pathogenic, in a patient with neurodevelopmental impairment, expanding the ...
New Method Maps the Fatty Landscape of the Cell’s Protein Factory
A new immunoisolation method called mammalian MemPrep delivers a high-confidence lipid and protein inventory of the endoplasmic reticulum in HEK293T ...
Tobacco Gene NtHHL5 Acts as a Brake on Cold Tolerance by Reshaping Membrane Lipids
Silencing the NtHHL5 gene in tobacco improves cold tolerance by reshaping membrane lipids, boosting antioxidant defenses and activating CBF cold-response ...
Stress-triggered mitochondrial protein aggregates relay quality-control signals to the ER
Researchers report that stressed mitochondria form protein aggregates called SIMPAs that signal through GRP75 at mitochondria–ER contact sites to trigger ...
Mitofusin-blocking peptides shrink heart attack damage in mice
Cell-permeable peptides that modulate mitofusin conformations alter ER–mitochondria calcium transfer and infarct size in mice, with mitofusin inhibition limiting cardiac ...
New isolation method maps the lipid makeup of the endoplasmic reticulum
An international team refined MemPrep to isolate the endoplasmic reticulum from mammalian cells, establishing that its tubules and sheets share ...
ITPR3 phosphosites show site-specific co-regulation in human phosphoproteomics
An integrative analysis of public human phosphoproteomics data identifies four recurrent ITPR3 phosphorylation sites with site-specific co-regulation and distinct patterns ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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