DNA Repair Protein RAD54L Protects Developing Egg and Sperm Precursors from Toxic Enzyme Traps
New research in mice reveals that the DNA repair factor RAD54L protects primordial germ cells by stabilizing the E3 ligase ...
Tag: E3 ubiquitin ligase
E3 Ligase TRIM37 Steers Cilia Growth by Tagging p62 and Tuning Autophagy
A new study reveals that the E3 ubiquitin ligase TRIM37 regulates primary cilium assembly by ubiquitinating the autophagy receptor p62 ...
New High-Throughput Screening Platform Accelerates the Hunt for Molecular Glue Degraders
Researchers have built a scalable transcriptomic screening platform that uses gene expression signatures and CRBN knockout cell models to systematically ...
Sacred Lotus Gene Offers New Shield Against Cadmium’s Toxic Grip
Scientists identified a lotus E3 ubiquitin ligase, NnRNF217, that boosts cadmium tolerance in plants by supercharging antioxidant enzyme activity and ...
Dual PROTACs Close In on Two Disease Proteins at Once
A new review in Molecular Diversity charts the rapid rise of dual PROTACs, single molecules engineered to destroy two disease-driving ...
Silencing SCAMP3 Eases Hypoxic Pulmonary Hypertension by Engaging the Ubiquitin Ligase WWP1
New research shows that silencing the membrane protein SCAMP3 reduces vascular remodeling in hypoxic pulmonary hypertension, apparently by restoring levels ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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