MG53 degrades AMPKα and suppresses bladder cancer in preclinical models
Preclinical tissue, cell, and xenograft experiments found that MG53 promoted AMPKα degradation, reduced glycolytic metabolism and tumor growth, and increased ...
Tag: E3 ubiquitin ligase
Single ubiquitin tags on non-histone proteins shape health and disease
A comprehensive review in Cellular and Molecular Life Sciences maps how single ubiquitin marks on non-histone proteins regulate DNA repair, ...
Two protein tags talk to each other and steer cancer’s fate
A new review in Genes & Diseases maps how arginine methylation and ubiquitination continuously regulate each other to influence cancer ...
CRISPR Screen Maps the Hidden Control Network of the Body’s Pollution-Sensing Receptor
A genome-scale CRISPR screen in human hepatocytes has revealed an extensive network of regulators governing the aryl hydrocarbon receptor, including ...
Light-Activated Molecular Degraders Put Protein Destruction Under Remote Control
Chemists have developed ruthenium-based photocaged PROTACs, called RuPHOTACs, that can be switched on with low-energy red light to selectively degrade ...
Fish-Specific Ubiquitin Ligase NHRE3 Helps Virus Evade Antiviral Defenses by Degrading ISG15
Researchers identified a fish-specific E3 ubiquitin ligase, NHRE3, that suppresses antiviral immunity in grass carp and rare minnows by tagging ...
DNA Repair Protein RAD54L Protects Developing Egg and Sperm Precursors from Toxic Enzyme Traps
New research in mice reveals that the DNA repair factor RAD54L protects primordial germ cells by stabilizing the E3 ligase ...
E3 Ligase TRIM37 Steers Cilia Growth by Tagging p62 and Tuning Autophagy
A new study reveals that the E3 ubiquitin ligase TRIM37 regulates primary cilium assembly by ubiquitinating the autophagy receptor p62 ...
New High-Throughput Screening Platform Accelerates the Hunt for Molecular Glue Degraders
Researchers have built a scalable transcriptomic screening platform that uses gene expression signatures and CRBN knockout cell models to systematically ...
Sacred Lotus Gene Offers New Shield Against Cadmium’s Toxic Grip
Scientists identified a lotus E3 ubiquitin ligase, NnRNF217, that boosts cadmium tolerance in plants by supercharging antioxidant enzyme activity and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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