How HIV-1’s Vpr Protein Hijacks a Human Degradation Machine to Destroy Diverse Targets
New cryo-EM structures reveal how the HIV-1 protein Vpr reshapes the human CRL4(VprBP) E3 ligase to degrade host substrates of ...
Tag: E3 ligase
Scientists discover the molecular switch that lets TNF trigger cell death
A new study identifies the E3 ubiquitin ligase HERC4 as the long-sought molecular switch that licenses RIPK1 to initiate TNF-induced ...
Cells Tag Faulty Glycogen for Destruction, Study Reveals
Researchers have discovered that the E3 ubiquitin ligase RNF213 directly tags aberrant, poorly branched glycogen for autophagic degradation, revealing a ...
PROTACs Move From Lab Concept to Clinical Reality in Targeted Protein Degradation
A new comprehensive review in Discover Chemistry details how PROTACs have evolved from a mechanistic concept into clinically advanced degraders ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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