Norrin complex structure guides potent engineered signaling surrogates
A structural study shows how Norrin, FZD4, TSPAN12 and LRP5 assemble, enabling engineered surrogate proteins with enhanced signaling potency.
Tag: complex
Angelman syndrome mice show disrupted Kv4.2 channel redistribution
A mouse study links loss of UBE3A to impaired Kv4.2–DPP6 complex remodeling and weakened dendritic channel gradients associated with excitability ...
P2RX2 exon-2 indel disrupts splicing and reduces receptor output in one DFNA41 family
A single-family functional study found that a heterozygous P2RX2 exon-2 insertion-deletion caused aberrant splicing and reduced P2X2 output, supporting a ...
Alpine moth study separates two species using anatomy and DNA barcodes
A study of alpine tortricid moths used male anatomy, DNA barcodes and museum specimens to distinguish Dichrorampha velata from D. ...
Empagliflozin stabilizes electrical activity in failing heart cells
Three-hour pretreatment with empagliflozin reduced multiple electrophysiological signs of arrhythmia in isolated mouse and rabbit heart cells from two non-ischemic ...
Model reveals dual-mode vibrations in pipes under internal and external flows
A nonlinear numerical model shows that internal and external flows can couple the first and second bending modes of a ...
The Antibiotic Resistance Benchmark PAβN Gets a Long-Overdue Toxicity and Structural Makeover
For more than two decades, one small molecule has quietly underpinned nearly every effort to sabotage the molecular garbage disposal ...
New wolf fish species with mythical head name found in Brazil’s Munim River
Deep in the Munim River basin of Maranhão state, northeastern Brazil, a predatory fish has been hiding in plain sight. ...
Two new bell-voiced frog species discovered in Madagascar’s Ranomafana rainforest
Two cryptic new frog species from Ranomafana National Park, one with a bell-like call and one that trills from caves, ...
Ancient Jetyasar Cosmetic Powder Reveals Silk Road Trade in Aromatic Oils
A complex analytical study of chalk pieces from 2nd–4th century AD female burials in Kazakhstan reveals that the Jetyasar people ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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