Hydrogen Sulfide Targets TrxR1 to Ease Diabetic Vascular Damage
New research reveals that hydrogen sulfide protects against diabetic vascular damage by modifying thioredoxin reductase 1, thereby suppressing inflammatory pathways ...
Tag: Cell Death Discovery
Powering the Niche: Mitochondrial Gene Mppa Steers Sperm Stem Cells in Fruit Flies
A new study in Cell Death Discovery shows that the conserved mitochondrial protein Mppa maintains the Drosophila testis stem cell ...
Tissue transglutaminase 2 revealed as an unexpected stabilizer of blood clots
A new study in Cell Death Discovery shows that the ubiquitous enzyme transglutaminase 2, long overshadowed by Factor XIIIa, helps ...
How a Ubiquitin-Editing Enzyme in Microglia May Drive Alzheimer’s Inflammation
A new study identifies CYLD as a deubiquitinase that stabilizes microglial IKKβ, driving NF-κB–NLRP3 signaling, neuronal pyroptosis, and cognitive decline ...
Starving the Sprouts: Cutting a Single Protein Slows Blinding Eye Disease in Mice
New mouse research shows that removing the protein lipocalin-2 from blood vessel cells curbs the destructive retinal vessel growth of ...
Diabetes Drug Metformin Shields Lymphatic Vessels from Chemotherapy Damage
New research shows that the diabetes drug metformin protects lymphatic vessels from mitochondrial damage caused by the chemotherapy agent 5-fluorouracil ...
Macrophage Enzyme MMP14 Helps Tumors Build an Immune Shield, Study Finds
A new study shows that the macrophage enzyme MMP14 generates soluble semaphorin 4D, a signal that builds an immunosuppressive tumor ...
Starvation enzyme SIRT2 strips a mitochondrial gatekeeper to trigger cell death
Researchers at Army Medical University show that during prolonged starvation the deacetylase SIRT2 moves into mitochondria, removes an acetyl group ...
Nerve Growth Factor Shows Promise Against Glaucoma by Calming Oxidative Stress and Brain Inflammation
New research in Cell Death Discovery shows that recombinant human nerve growth factor protects retinal ganglion cells in a glaucoma ...
Why Mature Human Sperm Resist TNF-α: The TNFR1 Apoptotic Shield Explained
New research shows that mature human spermatozoa resist TNF-α-induced apoptosis because their surface TNFR1 receptors cannot assemble the downstream signaling ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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