Macrophages Take Center Stage in the Battle Against Sepsis
A new review argues that macrophages, through their polarization, metabolic reprogramming and autophagy, hold the key to understanding sepsis and ...
Tag: autophagy
CRISPR Screen Reveals How Ovarian Cancer Cells Resist Niraparib
A genome-wide CRISPR screen identifies UGCG-driven sphingolipid metabolism and protective autophagy as drivers of Niraparib resistance in ovarian cancer.
Blue light disrupts DNA repair in skin cells through an ITGB3–PI3K/AKT pathway, study finds
A new study reports that blue light triggers autophagy imbalance and defective DNA damage repair in keratinocytes by raising ROS, ...
Iron-Engineered Nanoplatform Delivers DMDD and Targets Immune Checkpoints in Breast Cancer Model
An iron-engineered mesoporous organosilica nanoplatform improved delivery of the natural compound DMDD and inhibited breast tumor growth in preclinical models ...
AP2A1 emerges as a possible switch between senescence and rejuvenation in human cells
A new review in Discover Aging examines how the AP2A1 protein, long known for its role in clathrin-mediated endocytosis, has ...
Varenicline’s molecular mechanisms in neuropsychiatric disorders reviewed
A new review examines how the α4β2 nicotinic receptor agonist varenicline might act on molecular pathways involved in neuropsychiatric disorders.
Lck kinase fine-tunes T cell activation by phosphorylating autophagy receptor p62
A new EMBO Reports study shows that the kinase Lck phosphorylates the autophagy receptor p62 at tyrosine 433 within minutes ...
Research report: NLRC4 Acts as a Non‐Canonical Tumour Suppressor in Lung Adenocarcinoma by Inhibiting PI3K/AKT/mTOR Signalling to Induce Protective Autophagy
A new study shows that the immune sensor NLRC4 acts as a tumour suppressor in lung adenocarcinoma by restoring PTEN ...
Multi-omics study links autophagy and ER stress to PFOA toxicity in sperm precursor cells
A multi-omics study in GC-1 spermatogonial cells links PFOA exposure to altered autophagy, ER stress signaling and oxidative imbalance, with ...
Traditional Chinese Medicine Formula Shows Ovarian Protection in Rat Study
A rat study published in Biological Research reports that Dingkun Pill reduced oxidative stress, follicular depletion, and cell death in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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