Microglia Move to Center Stage as Alzheimer’s Therapies Enter a New Era
A new review maps how next-generation therapies targeting the brain's resident immune cells could reshape Alzheimer's disease treatment beyond amyloid-centric ...
Tag: APOE
Machine learning finds Non-APOE gene signals too weak to predict Alzheimer’s
A Korean two-stage sequencing study found that Non-APOE candidate variants added almost no predictive power once leakage and APOE effects ...
Shared retinal variants point to familial clustering of neovascular macular degeneration in two Saudi siblings
A phenotype-exome analysis of two Saudi siblings with neovascular age-related macular degeneration identified shared rare retinal variants, including HMCN1 p.Asn2980Thr, ...
New study tracks amyloid-beta and blood-brain barrier leakage in CAA
A new protocol study will track longitudinal changes in cerebrospinal fluid amyloid-beta peptides and blood-brain barrier dysfunction in cerebral amyloid ...
APOE gene variants shape heart disease risk, but South Asia tells a different story
A narrative review finds the APOE ε4 allele consistently raises ischemic heart disease risk worldwide, yet South Asians carry it ...
How Cardiovascular Health Shapes Lifespan: What the Evidence Shows
A comprehensive review maps how genetics, inflammation, metabolism, lifestyle, and environment converge on the cardiovascular system to shape human lifespan—and ...
Diffusion augmentation boosts cognitive-impairment classification in 542-person ADNI study
A diffusion-based augmentation strategy improved a neural network’s classification of cognitive impairment in a 542-participant ADNI study, raising held-out AUC ...
Sea Cucumber Fucoidan Eases Atherosclerosis in Mice by Rewiring Cholesterol Traffic
A sulfated fucoidan from the sea cucumber Pearsonothuria graeffei reduced arterial plaques and improved blood lipids in atherosclerosis-prone mice by ...
APOE ε4 gene variant accelerates age-related Alzheimer blood biomarker changes
A study of nearly 6,000 people shows the APOE ε4 variant steepens age-related shifts in plasma biomarkers of Alzheimer's disease, ...
Redesigned lipid nanoparticles steer mRNA away from the liver and toward target tissues
Researchers redesigned lipid nanoparticles to cut liver accumulation of locally injected mRNA by up to eighty-fold in mice while preserving ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!