Chemical Tags on Brain DNA Reveal How Alzheimer’s Risk Genes Do Their Damage
A large postmortem study identified 107 brain DNA methylation sites linked to Alzheimer's pathology and showed that methylation partially mediates ...
Tag: APOE
Protective APOE2 Gene Softens the Damage Wrought by Alzheimer’s Risk Gene APOE4
New research in mice shows that the protective APOE2 allele actively counteracts amyloid plaque buildup, microglial dysfunction, and proteomic changes ...
Fats in the Brain: How Lipid Imbalance May Drive Alzheimer’s Before Symptoms Appear
A new review in BMC Medicine argues that disrupted lipid homeostasis is an early, measurable, and modifiable driver of brain ...
APOE-Stratified Genome-Wide Study Reveals Hidden Genetic Architecture of Alzheimer’s Disease
A large APOE-stratified genome-wide association study reveals that Alzheimer's disease genetic risk variants have effects that are either amplified or ...
Neuropathology-centered approach opens new era for Alzheimer’s disease genetics
A new review argues that shifting Alzheimer's disease genetic research from clinically diagnosed cohorts to neuropathologically confirmed ones is revealing ...
New Four-Axis Framework Maps the Hidden Diversity of Atypical Alzheimer’s Disease
A new review proposes a four-axis framework of clinical phenotype, biological context, network topography, and tempo to define the heterogeneity ...
Long-Lived Parents May Signal Slower Biological Ageing, Swedish Study Finds
A six-year Swedish cohort study finds that having long-lived parents predicts better cognition, less inflammation, healthier lipids and slower accumulation ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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