Designed From Scratch: Microproteins Take Aim at Brain Disease
De novo designed microproteins, built computationally to bind toxic amyloid fibrils and restore mitochondrial function, are emerging as promising candidates ...
Tag: amyloid fibrils
New Web Server Predicts Amyloid Fibril Structures from Peptide Sequences
A new multiscale web server called InRegPep generates ensembles of amyloid protofilament models that matched experimental structures within 5 angstroms ...
When Lymphoma Masquerades as Kidney Disease: A Rare Case of Light Chain Amyloidosis
A rare case report describes severe renal light chain amyloidosis arising from low-grade B-cell non-Hodgkin lymphoma, diagnosed through renal biopsy ...
How Molecular Flux and Rigid β Motifs Drive Fibril Growth at Condensate Interfaces
New simulations reveal that rigid β-prone motifs and the rate of molecular delivery jointly determine whether aging condensate interfaces spread ...
Crowded and Squeezed: How Narrow Blood Vessels Trigger Heart Amyloid Buildup
Researchers at The University of Osaka showed that shear stress combined with confined geometry drives amyloidogenic light chain proteins to ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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