The catalytic synthesis of many abiotic organic compounds is beyond the native capabilities of mammalian cells. Broadening the range of physiologically compatible, bond-forming catalytic reactions could enable the in situ synthesis of diverse molecules within living systems. By controlling these reactions in both specific cells and in physical space, this approach could offer transformative ways to modulate cellular behaviour and treat cells as distinct reaction vessels within organisms. Here we use genetic targeting to incorporate organic photocatalytic dyes onto and within cells to enable cell-type-specific and spatially defined catalysis. Photocatalysis can be restricted to individual cells using mild, green-to-red visible stimulation. The dyes catalyse cross-dehydrogenative C–H functionalization for the light- and cell-specific construction of C–C bonds in situ. Nuclear-localized assembly directs protein translocation with reversed transport directionality, illustrating the utility of this approach to both generate and enhance the function of chemical biology tools. We anticipate that the integration of synthetic catalysts with cell-specific targeting may lay an important foundation for future precision-directed abiotic chemical synthesis in living organisms.
Zhao, S., Loh, K.Y., Tyson, J. et al. Genetically targeted photocatalytic organic dyes for spatiotemporally controlled organic synthesis in specific living cells.
Nat. Chem. (2026). https://doi.org/10.1038/s41557-026-02195-6
https://doi.org/10.1038/s41557-026-02195-6 bu içeriği 600 ile 800 kelime arasında olacak şekilde ve alt başlıklar ve madde içermiyecek şekilde ünlü bir science magazine için İngilizce olarak yeniden yaz. Teknik açıklamalar içersin ve Viral science news olacak şekilde İngilizce yaz. Haber dışında başka bir şey içermesin. Haber içerisinde 8 ile 10 paragraf olsun ve toplam uzunluk 600 ile 800 kelime arasında kalsın. Cevapta sadece haber olsun. Ayrıca haberi yazdıktan sonra içerikten yararlanarak aşağıdaki başlıkların bilgisi var ise haberin altında doldur. Eğer bilgi yoksa ilgili kısmı yazma.:
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Zhao, S., Loh, K.Y., Tyson, J. et al. Genetically targeted photocatalytic organic dyes for spatiotemporally controlled organic synthesis in specific living cells.
Nat. Chem. (2026). https://doi.org/10.1038/s41557-026-02195-6
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DOI: https://doi.org/10.1038/s41557-026-02195-6
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