Chronic pain remains one of the most pervasive and debilitating conditions worldwide, affecting approximately one in five adults. Manifesting in various forms—from persistent back pain and migraines to arthritis, long-term effects of concussions, and complications after cancer treatments—chronic pain poses major challenges both medically and socially. Conventional approaches primarily focus on pharmacological interventions, yet medications often fail to provide adequate relief, and long-term use raises concerns about side effects and dependency. A groundbreaking review published in The Lancet now sheds light on the neurobiological underpinnings of psychological therapies that offer promising alternatives to traditional pain management.
For decades, it has been observed clinically that psychological treatments can mitigate the subjective experience of pain. However, what has remained elusive is an intricate understanding of the mechanisms through which these therapies enact physical changes in the nervous system. Prior studies have often yielded inconsistent results, typically limited by small sample sizes and heterogeneity in methodologies. The review led by Professor Lene Vase from Aarhus University’s Department of Psychology bridges these gaps by synthesizing data across multiple investigations, revealing a compelling narrative of how mind and brain interact in the modulation of chronic pain.
One of the central revelations emerging from this synthesis is that psychological therapy does not merely offer symptomatic relief through distraction or altered perception. Instead, these interventions prompt tangible neuroplastic changes within key brain networks implicated in pain processing and emotional regulation. This demonstrates that therapeutic cognitive and emotional shifts reorganize neural circuitries, influencing the pain signals processed in both the brain and spinal cord. These findings offer a rare window into how mind-based therapies can effectuate physiological change, blurring the boundary between psychological experience and physical alteration.
The review emphasizes the role of cognitive behavioural therapy (CBT) as a particularly efficacious approach. CBT targets automatic, habitual thought patterns—those mental processes that operate beneath conscious awareness when the brain is essentially functioning on "autopilot." Neurologically, this autopilot state corresponds to the activity of the default mode network (DMN), a constellation of brain regions that deactivate during task-oriented behavior but become active during introspective thought and self-referential processing. Intriguingly, the DMN maintains robust connections with other brain networks that govern pain perception and emotional response. Through CBT-induced shifts in cognition and emotion, the activity within these networks is modulated, leading to a measurable decrease in pain experience.
Understanding the DMN’s involvement opens new horizons in chronic pain research. Chronic pain patients often report being trapped in ruminative loops, incessantly focusing on their discomfort and its implications. These cognitive-emotional entanglements amplify the pain sensation and impair quality of life. CBT endeavors to "loosen" these maladaptive thought patterns, enabling sufferers to reinterpret their pain in less threatening terms, reengage with daily life, and reduce avoidance behaviors. The neurobiological counterpart to this therapeutic success is altered functional connectivity in the DMN and related pain-processing networks, suggesting that lasting relief is anchored in brain plasticity.
Beyond the cerebral cortex, the spinal cord also plays a pivotal role as a relay and modulation center for pain signals ascending to the brain. Psychological treatments appear to influence spinal cord processing by adjusting the descending inhibitory pathways that typically suppress nociceptive inputs. This underlines a bidirectional dialogue between brain and spinal cord modulated by psychological states, situating chronic pain as not just a sensory phenomenon but a complex neuropsychological interplay.
Professor Vase highlights the transformative potential of these insights for clinical practice. With psychological therapies demonstrating neurobiological efficacy, the traditional paradigm that relegates pain management to pharmacology alone stands to be revolutionized. However, challenges remain. Access to trained psychologists is limited, and the demand for treatment far outstrips availability. Yet, there is optimism for expanding delivery models. Other healthcare practitioners, including physiotherapists, nurses, and primary care physicians, can potentially be trained to guide patients in adopting pain-relieving cognitive strategies.
Moreover, digital health interventions show promise as scalable solutions. Currently, over 500 applications purport to offer psychological support for pain management, though many lack rigorous scientific validation. Professor Vase advocates for apps grounded in cognitive behavioural principles, envisioning technology as a supplementary tool to extend therapeutic reach. The integration of neuroscience with digital therapeutics could democratize access to self-management tools and foster patient empowerment in chronic pain care.
This evolving understanding of chronic pain as a condition amenable to psychological modulation carries profound implications. It challenges the binary duality of mind versus body and underscores the importance of holistic approaches that harness the brain’s plasticity to alleviate suffering. Importantly, it signals a paradigm shift in which self-management and psychological insight emerge as core pillars alongside medical treatment and physical rehabilitation.
The review study, undertaken with rigorous methodology, did not involve external collaborators but was supported by an array of independent public and private funding bodies, reflecting broad recognition of the need for innovative pain research. The research team transparently disclosed potential conflicts of interest, ensuring the study’s credibility and alignment with ethical standards.
Current findings ignite hope for future investigations to delineate precisely which psychological components most significantly remodel the brain and spinal networks involved in pain. Such clarity will enable refinement of therapeutic techniques, optimization of treatment protocols, and personalization of interventions tailored to neurobiological profiles.
In sum, this seminal work published in The Lancet not only confirms that psychological therapies transcend perceived benefits to produce measurable neurobiological change but also illuminates pathways toward scalable, accessible solutions for millions suffering from chronic pain. The intersection of psychology, neuroscience, and technology offers a promising frontier for transforming chronic pain management and improving quality of life on a global scale.
Subject of Research: People
Article Title: Opportunities for chronic pain self-management: core psychological principles and neurobiological underpinnings
Web References: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00404-0/fulltext
Keywords: Chronic pain, cognitive behavioural therapy, default mode network, neuroplasticity, pain management, psychological treatment, brain networks, spinal cord, self-management, digital health, neurobiological mechanisms, pain modulation
