Biology
Epigenetic Boost Fails to Awaken Immune Therapy in Bile Duct Cancer Trial
A phase 2 trial found that the HDAC inhibitor entinostat combined with nivolumab produced no tumor responses in advanced cholangiocarcinoma,...
Enzyme GDH1 Keeps Breast Cancer Persister Cells Alive During Chemotherapy
New research shows that the mitochondrial enzyme GDH1 sustains drug-tolerant persister cells in triple-negative breast cancer by coordinating glutamine metabolism,...
PTPN6 Gene Emerges as Potential Prognostic Marker in Bladder Cancer
A new bioinformatics study links PTPN6 overexpression and promoter hypomethylation to overall survival in bladder cancer, positioning the gene as...
Why the Creamiest-Tasting Milk Isn’t Always the One You’d Expect
A new study of eight commercial UHT milk products shows that consumer liking depends on an integrated quality system of...
Peatland Rewetting Reshapes Mosquito Communities in Unexpected Ways, Study Finds
A two-year study in North-East German peatlands shows that Anopheles algeriensis thrives in rewetted bogs while Anopheles claviger clusters in...
Rising Interleukin-8 Levels in Blood May Signal Gastric Cancer Months Before Diagnosis
A prospective Egyptian cohort study found that rising serum interleukin-8 trajectories over 24 months predicted progression from H. pylori–associated precancerous...
Scientists Decipher the Chemical Language Spoken by Soil Bacillus Communities
A computational metabolomics study has mapped the shifting chemical profiles of Bacillus microbial consortia, creating a molecular lexicon that could...
RNA Messages Cross Kingdom Boundaries, Opening a New Era of Chemical-Free Crop Protection
A new review details how small RNA molecules travel between plants, fungi, bacteria, and viruses to regulate genes across kingdoms,...
Antimalarial Drug Artemotil Shows Promise Against Cartilage Scarring in Osteoarthritis
New research shows the antimalarial derivative Artemotil suppresses STC1-driven TGF-beta/SMAD2/3 signalling to reduce fibrotic cartilage remodelling in osteoarthritis models.
Immortalized lung macrophage cell line keeps primary-cell identity, offering new tool for respiratory research
Researchers have created an hTERT-immortalized mouse alveolar macrophage cell line that proliferates indefinitely while retaining the surface markers, gene expression...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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