Fatty Acid Nitroalkenes Show Promise in Taming LRRK2 Hyperactivation in Parkinson’s Disease
New research in npj Parkinson's Disease shows that fatty acid nitroalkenes can inhibit LRRK2 kinase hyperactivation and provide neuroprotection in...
Four Decades of Hunting the Misfolded Protein: How Prion Research Grew Into a Blueprint for Neurodegenerative Drug Design
A new review in Acta Neuropathologica chronicles four decades of Byron Caughey's pioneering work on prion disease inhibitors, from infrared...
New Single-Molecule Technique Reads Intact Tau Proteins at Unprecedented Scale
A new single-molecule technique called Iterative Mapping enables large-scale quantification of intact tau proteoforms in control samples, disease models, and...
Falling Levels of Immune Protein sCD30 in Spinal Fluid Track Huntington’s Disease Progression
A Swedish study confirms that the immune protein TNFRSF8 (sCD30) is halved in the cerebrospinal fluid of Huntington's disease gene...
Free Water Imaging in Parkinson’s Disease Demands Methodological Nuance, Study Argues
Researchers argue that free water imaging in Parkinson's disease produces method-dependent results that resist simple binary interpretation.
Human ALS Seeds Transmit Two Distinct SOD1 Aggregation Strains in Mice
Seeds prepared from the spinal cords of ALS patients homozygous for the SOD1 D90A mutation transmitted two distinct strains of...
TIMP2 Protein Levels and Gene Variants Trace Ageing and Neurodegeneration in Parkinson’s Disease
New research shows that cerebrospinal fluid TIMP2 levels rise with age and track neurodegeneration in Parkinson's disease, while TIMP2 gene...
Alzheimer’s Biomarkers Lose Their Grip on Memory as Age Rises Past 80
A naturalistic study of 676 Stockholm memory clinic patients shows that the associations between amyloid-beta 42 and medial temporal atrophy...
Plant-Derived Nanoparticles Show Promise Against Neurodegenerative Disease
A new review in 3 Biotech details how nanoparticles loaded with herbal compounds like curcumin and resveratrol could overcome the...
Black Pepper Compound Piperine Emerges as Powerful Potential Parkinson’s Drug in Landmark Study
A new computational study shows that piperine, the pungent alkaloid of black pepper, binds the Parkinson's-related MAO-B enzyme more strongly...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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