Blocked protein cleanup reroutes toxic TDP-43 cargo through extracellular vesicles
In motor neuron–like cells, inhibiting the proteasome or autophagy reshapes extracellular vesicle cargo and spreads proteotoxic stress to recipient cells.
Kurarinone curbs neuronal ferroptosis via ERα–NRF2/FTH1 pathway in Parkinson’s models
Kurarinone protected neurons from ferroptosis in cellular and mouse models of Parkinson's disease by activating an ERα-associated NRF2/FTH1 iron-sequestration pathway.
ADP-ribose, an NAD+ catabolite, drives neuronal ferroptosis through ENT2 inhibition
A new Nature Chemical Biology study identifies the NAD+ catabolite ADP-ribose as an inducer of neuronal ferroptosis through inhibition of...
Male mice hit harder by Parkinson’s-linked depression in new study
In an MPTP mouse model of Parkinson's disease, males developed stronger depressive- and anxiety-like behaviors alongside greater nigrostriatal degeneration, hippocampal...
HDAC isoform targeting offers a precision route to treating neurodegeneration
A new review argues that disease-specific HDAC isoforms, not broad-spectrum inhibition, should guide epigenetic drug development for neurodegenerative diseases.
Synthetic Receptors Rewired to Sense Amyloid Beta and Release Therapeutics in the Lab
A head-to-head laboratory comparison found that SNIPR and synNotch receptors, but not TRUCKs, supported amyloid beta-dependent expression of therapeutic transgenes...
Deep learning sharpens ultra-low-dose PET/MR scans in Alzheimer’s disease feasibility study
A retrospective feasibility study reports that a deep learning network substantially improved simulated ultra-low-dose multi-tracer PET/MR images in Alzheimer's disease,...
NF-κB1 Emerges as a Context-Dependent Switch in Neurodegenerative Disease
A new review argues that the NF-κB1 subunit's p105 and p50 proteins act as context-dependent regulators of neuronal survival and...
Blood Test for Early Alzheimer’s Detection Stays Stable Across Storage Conditions
A prospective observational study found that plasma pTau181 measured with the Elecsys Phospho-Tau (181P) immunoassay remained stable across varied sample...
Parkinson’s Disease Raises Fracture Risk, and Osteoporosis Care Must Keep Up
A new perspective article argues that osteoporosis prevention deserves far more attention in people with Parkinson's disease, especially when dementia...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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