About The Study: In this retrospective cohort study, hormone therapy was associated with protection against Alzheimer disease and related dementias in women age 65 or older with newly diagnosed breast cancer; the decrease in risk was relatively greater for Black women and women under age 75, while the protective effect of hormone-modulating therapy (HMT) diminished with age and varied by race in women. When deciding to use HMT for breast cancer in women age 65 years or more, clinicians should consider age, self-identified race, and HMT type in treatment decisions.
About The Study: In this retrospective cohort study, hormone therapy was associated with protection against Alzheimer disease and related dementias in women age 65 or older with newly diagnosed breast cancer; the decrease in risk was relatively greater for Black women and women under age 75, while the protective effect of hormone-modulating therapy (HMT) diminished with age and varied by race in women. When deciding to use HMT for breast cancer in women age 65 years or more, clinicians should consider age, self-identified race, and HMT type in treatment decisions.
Corresponding author: To contact the corresponding author, Chao Cai, Ph.D., email caic@mailbox.sc.edu.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi: 10.1001/jamanetworkopen.2024.22493)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
Journal
JAMA Network Open
Cite Scienmag News
Clara W. (July 16, 2024). Alzheimer disease and related dementia following hormone-modulating therapy in patients with breast cancer. Scienmag. https://scienmag.com/alzheimer-disease-and-related-dementia-following-hormone-modulating-therapy-in-patients-with-breast-cancer/
Clara W. "Alzheimer disease and related dementia following hormone-modulating therapy in patients with breast cancer." Scienmag, 16 July 2024, https://scienmag.com/alzheimer-disease-and-related-dementia-following-hormone-modulating-therapy-in-patients-with-breast-cancer/. Accessed 28 August 2026.
Clara W. "Alzheimer disease and related dementia following hormone-modulating therapy in patients with breast cancer." Scienmag. July 16, 2024. https://scienmag.com/alzheimer-disease-and-related-dementia-following-hormone-modulating-therapy-in-patients-with-breast-cancer/
