Alzheimer disease and related dementia following hormone-modulating therapy in patients with breast cancer

About The Study: In this retrospective cohort study, hormone therapy was associated with protection against Alzheimer disease and related dementias in women age 65 or older with newly diagnosed breast cancer; the decrease in risk was relatively greater for Black women and women under age 75, while the protective effect of hormone-modulating therapy (HMT) diminished with age and varied by race in women. When deciding to use HMT for breast cancer in women age 65 years or more, clinicians should consider age, self-identified race, and HMT type in treatment decisions.

Corresponding author: To contact the corresponding author, Chao Cai, Ph.D., email caic@mailbox.sc.edu.

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(doi: 10.1001/jamanetworkopen.2024.22493)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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