A phase 1b/2 trial found that the oral CBP–β-catenin inhibitor E7386 combined with lenvatinib produced durable responses in advanced endometrial cancer patients whose disease had progressed after platinum chemotherapy and anti-PD-(L)1 immunotherapy.
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A study of 1,938 male marathon finishers shows that rising air temperature selectively changes which runner characteristics, from personal best time to body mass index,...
One of the most persistent hopes in preventive medicine has been that a simple nutrient taken during pregnancy could lay the foundations of a child's...
A phase 1b/2 trial found that the oral CBP–β-catenin inhibitor E7386 combined with lenvatinib produced durable responses in advanced endometrial cancer patients whose disease had...
A critical narrative review finds that Pacific women's traditional knowledge of agriculture, water, marine resources and disaster recovery is foundational to climate resilience yet systematically...
A multimodal deep learning model combining histopathological images with clinical data achieved 97.17 percent accuracy in stratifying colorectal cancer patients into high- and low-risk groups.
Researchers in India have created a one-step iron, iron oxide and carbon nanocomposite that removes up to 88 percent of lead and 75 percent of...
Researchers have developed an amplification-free CRISPR-Cas13 assay that detects and distinguishes three quarantine-significant sugarcane viruses directly from plant RNA with a limit of detection of...
A systematic review of 48 studies finds that global ESG reporting frameworks are converging in structure while remaining divided over the fundamental purpose of sustainability...
Springer Nature has launched the Journal of Materials Science: Polymers, a Gold Open Access journal whose founding editorial by Maude Jimenez and Gregory C. Rutledge...
A formal aging study of 351 mice shows for the first time that blocking the growth hormone receptor with an antagonist, rather than genetic deletion,...
Researchers fused machine learning, molecular docking and molecular dynamics simulations into a virtual screening pipeline that discovered HY-18,623, a nanomolar dual inhibitor of the cancer-driving...
A comprehensive DFT and TD-DFT study has mapped the conjugated electronic structure of the antiviral compound methisazone, linking its donor-acceptor framework directly to its observed...
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