SLC5A12 Marks and Supports an Invasive State in HNSCC
SLC5A12 marked an invasive HNSCC state, and experimental knockdown reduced tumor-cell behaviors and xenograft growth in preclinical models.
Tag: xenograft models
TIMP1 linked to anoikis resistance and metastasis in esophageal cancer
Single-cell and bulk transcriptomic analyses linked TIMP1 to anoikis resistance in esophageal squamous cell carcinoma, while cell and mouse experiments ...
Systematic review of 14 in vitro studies links natural products to apoptosis in salivary gland mucoepidermoid carcinoma
A systematic review of 14 in vitro studies found that natural products showed antiproliferative and proapoptotic activity in human mucoepidermoid ...
EP300 Degradation and AKT Inhibition Slow Osteosarcoma in Preclinical Models
A PROTAC that degrades EP300 combined with AKT inhibition slowed tumor growth and extended survival in patient-derived osteosarcoma mouse models, ...
MG53 degrades AMPKα and suppresses bladder cancer in preclinical models
Preclinical tissue, cell, and xenograft experiments found that MG53 promoted AMPKα degradation, reduced glycolytic metabolism and tumor growth, and increased ...
β-Catenin Inhibitors Show Potent Activity Against Double-Mutant Endometrial Cancer in Preclinical Study
A new preclinical study shows that the β-catenin/CBP inhibitor ICG-001 selectively kills endometrial cancer cells carrying both PIK3CA and CTNNB1 ...
Radiation Supercharges Natural Killer Cell Therapy Against Liver Cancer in New Study
New research shows that radiation can make liver cancer cells more visible to natural killer cells, boosting the effectiveness of ...
New 5-FU Derivative EB-18 Shows Potency Against Resistant Cancers
Researchers have engineered EB-18, a phosphonium-substituted derivative of the classic chemotherapy drug 5-fluorouracil that outperforms 5-FU and standard agents in ...
Hidden RNA Tag Drives Paclitaxel Resistance in Bladder Cancer, Study Finds
Researchers report that the RNA-binding protein IGF2BP3 stabilizes m6A-tagged CENPA mRNA to fuel paclitaxel resistance in bladder urothelial carcinoma, identifying ...
Plant Compound Trifolirhizin Shows Multi-Target Promise Against Bladder Cancer
Researchers in China report that the natural pterocarpan flavonoid trifolirhizin suppresses bladder cancer proliferation, invasion, and immune evasion while inducing ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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