How Hippo, Wnt, NRG1 and Notch pathways could unlock heart regeneration
A new review synthesizes the signaling pathways, extracellular matrix cues, metabolic switches and transcription factors that govern cardiomyocyte proliferation and ...
Tag: Wnt signaling
Moth Wing Shape Altered in Lab First, Backing Butterfly Cookie-Cutter Idea
A seven-year experiment has for the first time altered the shape of moth wings, supporting the idea that moths and ...
Nuclear CK1α joins the WNT transcription machine to drive tumor-initiating cells
Nuclear L-insert-containing CK1α isoforms act as positive components of the β-catenin/TCF complex, while pharmacological CK1α activation with SSTC3 depletes WNT-driven ...
Blocking Two Opposing Signals Steers Repair Cells Back to Rebuilding Myelin in Mice
In a mouse model of demyelination, OPCs shift toward an astrocyte-like state through opposing BMP and Wnt signaling, and blocking ...
Alx4 keeps its limb-building role even as its expression shifts across amniotes
A new study finds that the Alx4 gene shows divergent limb bud expression in chicken and mouse, yet its protein ...
Wnt Signaling and CDX2/T/TBX6 Axis Drive Human Urine Cell Reprogramming into Presomitic Mesoderm
A new study maps how Wnt/β-catenin signaling and the Dot1L inhibitor EPZ5676 coordinate the reprogramming of human urine-derived cells into ...
PYGO2 and MAML1 expression linked to early-stage papillary thyroid cancer
A study of sixty papillary thyroid carcinoma tumors found that PYGO2 and MAML1 expression levels were significantly higher in early-stage ...
Culture Medium Rewrites Drug Sensitivity in Patient-Derived Tumor Organoids
A new study shows that the choice between Wnt-based and OncoPro culture medium reshapes the transcriptional state and drug sensitivity ...
Review proposes SFRP4–integrin interaction may restrain tumor angiogenesis
A 2026 review proposes that SFRP4 may inhibit tumor angiogenesis through integrin-linked disruption of Wnt–β-catenin signaling, but the supplied evidence ...
LF3 restores 5-FU sensitivity in resistant colorectal cancer cell model
LF3 inhibited Wnt/β-catenin signaling and restored 5-fluorouracil sensitivity in a preclinical HCT-116 cell model of long-term chemotherapy resistance.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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