Review proposes SFRP4–integrin interaction may restrain tumor angiogenesis
A 2026 review proposes that SFRP4 may inhibit tumor angiogenesis through integrin-linked disruption of Wnt–β-catenin signaling, but the supplied evidence ...
Tag: Wnt signaling
LF3 restores 5-FU sensitivity in resistant colorectal cancer cell model
LF3 inhibited Wnt/β-catenin signaling and restored 5-fluorouracil sensitivity in a preclinical HCT-116 cell model of long-term chemotherapy resistance.
Novel CTNNB1 missense variant identified in child with spastic diplegia and visual defects
A 7-year-old Iranian boy with a previously unreported CTNNB1 missense variant showed developmental delay, spastic diplegia, microcephaly, behavioral problems and ...
Faulty Connexin 43 Gene Reveals Hidden Signaling Switch Behind Rare Bone Disorder
A new study shows that GJA1 mutations in oculodentodigital dysplasia suppress Wnt/c-MYC signaling, driving a paradoxical inflammatory imbalance and excessive ...
Brazilian Anti-Cancer Plant Yields Three New Molecules and a Structural Surprise
A comprehensive phytochemical study of a Brazilian medicinal plant has yielded three new bioactive molecules, revised the structures of two ...
Giant River Prawn Embryos Reveal a Dramatic Genetic Handover From Mother to Embryo
A new transcriptomic study maps eight embryonic stages of the giant river prawn, revealing a massive early genetic shift consistent ...
Master Gene Switches in the Brain Emerge as New Drug Targets for Psychiatric Disease
A new review in Translational Psychiatry identifies the TCF/LEF transcription factor family as central nuclear effectors of Wnt/β-catenin signaling and ...
Single-Cell Map Reveals How Embryonic Ducts Build or Abandon the Female Reproductive Tract
Single-cell transcriptomics in chicken embryos reveals the molecular programs that build the female Müllerian duct and drive its regression, identifying ...
β-Catenin Inhibitors Show Potent Activity Against Double-Mutant Endometrial Cancer in Preclinical Study
A new preclinical study shows that the β-catenin/CBP inhibitor ICG-001 selectively kills endometrial cancer cells carrying both PIK3CA and CTNNB1 ...
Ancient Jumping Genes Help Explain How DNA Variants Shape the Human Cortex
A massively parallel reporter assay of 9,092 cortical-structure-associated variants reveals that Alu retrotransposons, Wnt signaling and transcription factor expression jointly ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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