Wnt Pathway Dysfunction Linked to Down Syndrome Cell Stress
A study in BMC Molecular and Cell Biology finds that Wnt/β-catenin pathway suppression in Down syndrome amniocytes is linked to ...
Tag: Wnt signaling
Superficial Fascia Telocytes Exhibit Layer-Adapted States and Interfacial Communication Potential
Researchers identified layer-adapted states of Cd34+Pdgfra+ telocytes across the ventral body wall continuum, highlighting their potential role in interfacial intercellular ...
UBE2K-FBXO11 Complex Activates Wnt Signaling by Stabilizing Beta-Catenin via Polyubiquitination
A genome-wide CRISPR screen reveals that the UBE2K-FBXO11 complex stabilizes beta-catenin through K63-linked polyubiquitination to promote Wnt signaling and cancer ...
RAS Mutations Reshape Chromatin Architecture and WNT Signaling in Colorectal Cancer
Researchers utilizing isogenic colorectal cancer models demonstrated that KRAS and BRAF mutations alter chromatin accessibility and transcriptional programs with convergent ...
AGS Compounds Boost TERT and Reduce Amyloid Plaques in Alzheimer’s Mice
Daily subcutaneous administration of synthetic tri-aryl AGS compounds elevated protective telomerase reverse transcriptase, reduced amyloid beta plaque burden, and improved ...
WNK Kinases Regulate RNF43 Cell Surface Levels to Modulate WNT Signaling
Researchers have discovered that WNK family kinases regulate the cell surface abundance and ubiquitination of the E3 ubiquitin ligase RNF43, ...
Elastin peptides in silk hydrogels aid cranial bone repair
A new study reveals that elastin peptides in silk fibroin hydrogels promote cranial bone regeneration by epigenetically regulating the ROCK1/Wnt/β-catenin ...
Manta Ray Fin Splitting Is Initiated by Wnt Pathway Inhibitor DKK1
Researchers have demonstrated that applying the Wnt antagonist DKK1 to little skate embryos arrests apical ectodermal ridge signaling and truncates ...
MicroRNA Out-Seed Variants Linked to Breast Cancer Subtypes in Vietnamese Women
An exploratory case-control study of 100 Vietnamese women identified preliminary associations between three microRNA out-seed variants regulating WNT and NOTCH ...
Sclerostin Protein Linked to Peripheral Bone Loss in Premenopausal Rheumatoid Arthritis
A case-control study reveals that premenopausal women with rheumatoid arthritis exhibit elevated serum sclerostin levels that correlate inversely with peripheral ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!