How Losing p53 Lets Mutant Cells Colonize Healthy Tissue: A Wnt Gradient Revealed
A Mount Sinai study published in Science shows that loss of the tumor suppressor p53 reorganizes Wnt signaling into a ...
Tag: Wnt signaling
The Brain May Be Built From Two Separate Embryonic Lineages
A new Nature Neuroscience study shows that the mammalian brain is assembled from two parallel lineage-restricted progenitors that emerge simultaneously ...
FDA-Approved Antibiotics Show Promise Against Wnt-Driven Colorectal Cancer
Researchers used virtual drug repurposing to identify FDA-approved antibiotics Carbenicillin and Ceforanide as inhibitors of the β-catenin/Tcf4 interaction, showing anti-proliferative ...
Lost Epigenetic Guardian CBX7 Emerges as Key Driver and Drug Target in Glioblastoma
A new review shows that the epigenetic regulator CBX7 acts as a tumor suppressor in glioblastoma, and that restoring its ...
New Molecular Driver of Atherosclerosis Identified: PLCE1 Pushes Artery Disease Forward
New research in Cell Death Discovery shows that the enzyme PLCE1 worsens atherosclerosis by damaging endothelial function and fueling macrophage ...
Tiny Protein Helix Found to Guide the Cells That Build Tooth Enamel
A short membrane-binding helix within the enamel protein ameloblastin has been shown to direct the polarity of enamel-forming cells and ...
Scientists Map the Master Plan for Rebuilding the Human Gut with Stem Cells
A landmark roadmap from the NIH-backed Intestinal Stem Cell Consortium details how intestinal stem cells and their niches could be ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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