FBXO28 ubiquitinates BRD4 to fuel lung cancer cell malignancy
A study in non-small cell lung cancer models found that FBXO28 promotes proliferation, migration and invasion by ubiquitinating BRD4 and ...
Tag: ubiquitination
White birch study links deubiquitinase BpUBP3 to pollen growth
A white birch study identified 56 deubiquitinase genes and found experimental evidence that BpUBP3 contributes to pollen germination and pollen-tube ...
New Study Identifies UBA1 as a Key Biomarker in Multiple Myeloma
A new study identifies UBA1 as a primary candidate biomarker for multiple myeloma by integrating ubiquitination and liquid-liquid phase separation ...
Two protein tags talk to each other and steer cancer’s fate
A new review in Genes & Diseases maps how arginine methylation and ubiquitination continuously regulate each other to influence cancer ...
Kidney Injury Gene Switch Discovered in Immune Cells Offers New Treatment Hope
A newly identified protein circuit in macrophages controls inflammatory kidney damage, and a natural compound can restore it.
TRIP13 shields a key metabolic enzyme from destruction, helping colorectal cancer adapt and resist chemotherapy
TRIP13 protects LDHA from FBXW7-mediated degradation, sustaining a lactate-driven antioxidant program that helps colorectal cancer cells adapt to hypoxia and ...
The Tumor Suppressor CYLD: A Molecular Switchboard Controlled by Chemical Tags
A new review reveals how the tumor suppressor and deubiquitinating enzyme CYLD is switched on and off by phosphorylation, ubiquitination, ...
Hidden Protein Switches That Keep Bones in Balance May Reshape Osteoporosis Research
A new BMC Medicine review maps how post-translational modifications act as a networked control layer that gates, amplifies, and dampens ...
Hidden RNA Molecule Drives Ovarian Cancer by Stabilizing Two Key Oncoproteins
A long non-coding RNA called RBMS3-AS3 has emerged as a powerful molecular accomplice in ovarian cancer, according to a new ...
USP28 enzyme drives deadly blood vessel damage in sepsis, mouse study reveals
Researchers identify a USP28–NMMHC IIA signaling loop that accelerates endothelial cell death and multi-organ injury in septic mice, revealing a ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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