PD-1 and LAG-3 Double-Positive T Cells Predict Better Gastric Cancer Survival
A multicohort study finds that gastric tumors rich in PD-1 and LAG-3 double-positive CD8 T cells—an activated, pre-exhausted population—are linked ...
Tag: tumor microenvironment
Dual T-Cell Activator Breathes New Life Into Checkpoint Therapy for Resistant Cancers
A selective dual T-cell activator directed at the TCR beta chain revives exhausted antitumor T cells and sensitizes checkpoint-resistant cancers ...
Scientists Decode Colorectal Tumors With Imaging and Multi-Omics Fusion
A new review in the Journal of Translational Medicine maps how radiomics, pathomics and multi-omics integration can decode the tumor ...
Novel Plasmid Combination Injected Directly into Tumors Drives Strong Regression of Metastatic Melanoma
Researchers report that a novel combination of plasmids delivered directly into tumors induces high levels of regression in metastatic melanoma, ...
Cell Death Turns Tumors Against Themselves in Combo Therapy for Pancreatic Neuroendocrine Cancer
New research shows that combining sunitinib with 177Lu-DOTATATE radiotherapy triggers immunogenic cell death in pancreatic neuroendocrine tumors, recruiting antitumor T ...
Scientists Map How Tumours Push Immune Cells Into Exhaustion
A review in Experimental & Molecular Medicine examines how chronic antigen exposure and a hostile tumour microenvironment reprogram T cells ...
China’s Cancer Research Shifts From Molecular Reductionism to Holistic Integrative Medicine
A new review maps how Chinese cancer research has evolved from single-target molecular reductionism toward a three-tier holistic integrative medicine ...
AI-Powered Cancer Drug Research Has Exploded Since 2018, Landmark 15,554-Study Analysis Reveals
A bibliometric analysis of 15,554 publications maps the explosive growth, global leaders, and future challenges of AI-driven anticancer drug design ...
Cholesterol Enzyme DHCR24 Emerges as Driver and Biomarker of Endometrial Cancer
New research identifies the cholesterol synthesis enzyme DHCR24 as a driver of endometrial carcinoma progression and a potential prognostic biomarker ...
How AI and Multi-Omics Are Unlocking the Hidden Microbial World Inside Tumors
A Genome Biology review charts how multi-omics technologies and artificial intelligence are transforming cancer microbiome research from observational associations toward ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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