Tumor Slice Cultures Reveal New Pitfalls in Testing AAV Gene Therapy for Glioblastoma
A new study shows that the choice of patient-derived culture model strongly shapes how AAV-mediated gene delivery performs in glioblastoma, ...
Tag: tumor microenvironment
Engineered fusogenic vaccinia virus arms IL-15 to reprogram tumors and boost antitumor immunity
Researchers engineered a fusogenic oncolytic vaccinia virus that displays IL-15Rα on infected tumor cells to locally trans-present IL-15, reprogramming the ...
Lab-Grown Tumor Organoids Illuminate How Cancers Evade, Tolerate, and Resist Treatment
A new review in Molecular Cancer positions patient-derived organoids as living systems for mapping how cancers tolerate, persist through, and ...
Silenced APP Protein Reveals Why Pediatric Brain Tumors Hide From the Immune System
An integrated multi-omics study shows that mesenchymal-like tumor cells drive myeloid recruitment in pediatric high-grade glioma and that reduced amyloid ...
CRISPR Screens Reveal DNMT3A’s Dual Role in Tumor Immune Evasion
In vivo CRISPR screens reveal that the epigenetic enzyme DNMT3A can both preserve and suppress tumor immune visibility, reshaping how ...
Tiny Cell Structures Called Migrasomes May Predict Gastric Cancer Outcomes
A new study links fibroblast-derived migrasome programs and the protein TSPAN4 to gastric cancer progression and builds a highly accurate ...
CYP2S1 enzyme linked to immunotherapy resistance in esophageal cancer
New research identifies the enzyme CYP2S1 as a driver of immunosuppressive cell recruitment and poor chemoimmunotherapy response in esophageal squamous ...
Immune Cells Inside Breast Tumours May Signal Spread to Lymph Nodes
A Malaysian study of 241 early breast cancer patients finds that higher levels of tumour-infiltrating lymphocytes are linked to lower ...
RNA Editing Enzyme ADAR1 Emerges as Key Switch That Turns Cold Bladder Tumors Hot
Researchers found that inhibiting the RNA editing enzyme ADAR1 reprograms the immunosuppressive tumor microenvironment of bladder cancer and sensitizes it ...
Scientists Reverse Radiotherapy Resistance in Lung Cancer by Rewiring the Immune Microenvironment
New research shows that lung tumors become radioresistant through ATR signaling activation and immune suppression, but innate immune agonists and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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