New AI tool maps single cells onto tissue space with unprecedented precision
A new deep learning framework called SCmapST uses a seeded matches strategy to map single-cell gene expression data onto spatial ...
Tag: tumor microenvironment
Epigenetic Boost Fails to Awaken Immune Therapy in Bile Duct Cancer Trial
A phase 2 trial found that the HDAC inhibitor entinostat combined with nivolumab produced no tumor responses in advanced cholangiocarcinoma, ...
How Aging Cells Secretly Help Tumors Grow—and How Scientists Hope to Stop Them
A new review in Cancer Reports details how the senescence-associated secretory phenotype can both suppress and fuel tumors, and how ...
Melanoma’s Genetic Blueprint Builds Immune-Proof Tumor Neighborhoods, Study Finds
Researchers at NYU Grossman School of Medicine show that loss of the NF1 tumor suppressor reorganizes melanoma tumors into immunosuppressive ...
Immune checkpoint VSIR fuels gastric cancer growth by amplifying AXL signaling
New research in iScience reveals that the immune checkpoint molecule VSIR drives gastric cancer progression by transcriptionally activating and post-translationally ...
Sugar Signature Reveals Which Tumor-Fighting T Cells Are Most Vulnerable
Researchers at Peking University have developed a single-cell method showing that low α2,6-linked sialylation marks the most potent tumor-reactive CD8+ ...
Three Ways to Die: How Ferroptosis, Cuproptosis and Pyroptosis Shape Cancer
A new Molecular Cancer review proposes an "interconnected death" framework showing how ferroptosis, cuproptosis, and pyroptosis interact through shared metabolic ...
Hypoxia Rewires RNA Methylation to Drive Pancreatic Neuroendocrine Tumor Growth
A new study reveals how low oxygen strips m6A methylation marks from tumor cell RNA, unleashing a signaling cascade that ...
Genomic and Transcriptomic Landscape of Spread Through Air Spaces in Stage 1 Lung Adenocarcinoma
A new study maps the genomic and transcriptomic features of spread through air spaces in stage 1 lung adenocarcinoma, offering ...
Jumping Genes May Ignite Immune Defenses in Stomach Cancers with DNA Repair Weaknesses
New research links LINE-1 retrotransposon overexpression and homologous recombination deficiency in gastric cancer to heightened immune pathway activation and potential ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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