Secreted FGF Carriers Emerge as Prognostic Biomarkers Across Cancers
A new review maps how the three secreted FGFBP proteins tune FGF signaling in physiology and act as divergent prognostic ...
Tag: tumor microenvironment
Tumor Cell State Linked to Low Angiogenesis Identified in Lung Adenocarcinoma
A SCGB3A2-high tumor cell state in lung adenocarcinoma shows low angiogenesis and is associated with extracellular PGK2 and angiostatin signals.
Spatial immune maps link B cells and T cell neighborhoods to colorectal cancer outcomes
Colorectal cancer prognosis has long been judged mainly by tumor stage and spread, but the immune cells living inside and ...
Cancer cells flood tumors with palmitate that exhausts CAR-T cells
Researchers report that the epigenetic regulator BAZ2A drives renal cancer cells to accumulate palmitic acid, which impairs CAR-T cell mitochondria ...
Deep Generative Model Integrates Multiscale Spatial Omics Across Diverse Tissues
Researchers have introduced CORAL, a probabilistic deep generative model that leverages graph attention to integrate multiscale spatial transcriptomic, proteomic, metabolomic, ...
Fibroblasts Feed Pancreatic Tumors Through Contact-Based Lipid Transfer, Study Finds
Cancer-associated fibroblasts deliver blood-borne cholesterol to pancreatic cancer cells and suppress T cell function through ANO6-dependent trogocytosis, a contact-based membrane ...
TAM receptors and STAT–SOCS signaling shape the immune landscape of thymic epithelial tumors
A new integrative analysis links TAM receptor and STAT–SOCS signaling to immune infiltration patterns in thymic epithelial tumors.
MRI signal patterns hint at immune landscape of liver cancer in exploratory study
An exploratory study found that arterial wash-in on dynamic contrast-enhanced MRI was inversely correlated with CD3-positive stromal lymphocyte infiltration in ...
Platelet-derived microparticles may drive acute myeloid leukemia progression and inspire nanoparticle drug delivery
A new review examines how platelet-derived microparticles may worsen acute myeloid leukemia by transferring molecular cargo to cancer cells, and ...
Organ-on-a-chip platform predicts chemotherapy response in colorectal cancer patients
A patient-derived organ-on-a-chip platform grown from colorectal tumor tissue reproduced chemotherapy sensitivity profiles across eight patients and showed early, preliminary ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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