Tag: tumor microenvironment

A new Nature Cancer study reveals that the kinase GSK3β in colorectal tumor cells drives fumarate accumulation that epigenetically reprograms ...

New preclinical research shows that the plant compound coumarin activates natural killer cells, boosts their mitochondrial energy supply, and shrinks ...

University of Oklahoma researchers have identified three adjacent cell subclusters in pancreatic tumors that form a feed-forward network driving cancer ...

A new review proposes co-designing oncolytic viruses and CAR-T or CAR-NK cells as a modular, self-amplifying therapeutic system to overcome ...

A new review maps how cancer-associated fibroblasts exclude immune cells from osteosarcoma tumors and outlines the therapeutic strategies that could ...

A new review describes how NMDA glutamate receptors on myeloid cells drive calcium-dependent reprogramming toward immunosuppressive states, and how blocking ...

Researchers have engineered a 3D-printed hydrogel scaffold that kills residual bone tumor cells through pH-responsive nanozyme catalysis, activates antitumor immunity ...

Researchers have developed and validated a 45-gene transcriptomic signature, Met-Score, that quantifies metastatic competence in primary prostate tumors and predicts ...

A new computational framework called CellART unifies cell segmentation and cell-type annotation across high-resolution spatial transcriptomics platforms, revealing single-cell detail ...

A new review in the Journal of Translational Medicine argues that c-MET signaling shapes spatially confined, metabolically driven immunosuppressive niches ...