Macrophage Enzyme MMP14 Helps Tumors Build an Immune Shield, Study Finds
A new study shows that the macrophage enzyme MMP14 generates soluble semaphorin 4D, a signal that builds an immunosuppressive tumor ...
Tag: tumor microenvironment
Molecular Scissors: Cysteine Peptidases Emerge as Master Switches of Antitumor Immunity
A new review in iMetaMed reveals how cysteine peptidases such as cathepsins B, S, L, and X control antigen presentation ...
Immune Cells Feed Breast Cancer Tumors as AI and DNA Testing Reshape Cancer Care
New MSK studies reveal that immune cells secretly feed triple-negative breast cancer, a CXCR2 blocker sensitizes leptomeningeal metastases to radiation, ...
Engineered Immune Cells Edge Closer to Becoming a Real Weapon Against Breast Cancer
A new review maps the engineering strategies, from dual-target receptors to tumor microenvironment remodeling, that could finally bring CAR-T cell ...
AI-Designed Protein Drug Recruits Immune Cells to Fight Gastric Cancer—With a Helping Hand from Dendritic Cells
A team at Nanjing Medical University used RFdiffusion to design a CLDN18.2-targeting T-cell engager for gastric cancer and showed that ...
R-Loop Gene Signature Predicts Survival and Immune Landscape in Esophageal Cancer
Researchers have built the first R-loop-related gene signature for esophageal squamous cell carcinoma, identifying BRIX1, CHEK1, and NUP155 as core ...
Hidden Prostate Cancer Patterns That Predict Deadly Disease Are Being Missed in Biopsies
A new Nature Reviews Urology review warns that intraductal and invasive cribriform prostate cancers are aggressive, genomically unstable and frequently ...
Lactate Fuels a Hidden Molecular Chain That Helps Liver Cancer Evade Immunity
A new study reveals how lactate-driven lactylation of histone and non-histone proteins in liver cancer activates a METTL3-FDFT1 cholesterol pathway ...
Cholesterol’s Hidden Geography: How Tumor Neighborhoods Fuel Resistant Prostate Cancer
A paired spatial multi-omics study of prostate cancer reveals that rising cholesterol during therapy tracks with castration resistance, as import-dominant ...
Curcumin Shows Promise Against Ovarian Cancer, but Nanotechnology May Hold the Key
A systematic review of 21 preclinical studies finds that curcumin and its nanoformulations modulate key cancer signaling pathways and enhance ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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