Tag: tumor microenvironment

Patient-derived organoid and xenograft models reveal that a collagen I-rich tumor matrix activates TGFβ signaling and LTBP2 expression, priming colorectal ...

An integrated multi-omics study of 112 Chinese cervical cancer patients reveals key driver mutations, immune phenotypes, and promising therapeutic targets.

New research in Advanced Science reveals that the secreted protein LRG1 drives pathological angiogenesis in bladder cancer by binding ANXA2 ...

A new review charts how immune cell engagers, from bispecific antibodies and aptamers to surface-engineered cells and nanoparticles, are being ...

Integrating single-cell and spatial transcriptomics, researchers identified a novel invasive-frontier fibroblast state and the multicellular community it defines, which independently ...

A ginseng-derived saponin suppresses pancreatic cancer in preclinical models by blocking the PI3K-AKT pathway and preventing macrophages from adopting a ...

A preclinical study shows that combining KRASG12D inhibition with CTLA-4 blockade dismantles a TGF-beta-driven regulatory T cell shield, sensitizing KRAS-mutant ...

A new review in Cancer Reports proposes that the extracellular matrix protein COL6A1, overexpressed in the fibrotic stroma of cholangiocarcinoma, ...

A new review identifies three fibroblast-driven mechanisms that make liver cancer cells resistant to kinase inhibitors and immunotherapy, while warning ...

A new review in Medical Oncology argues that tumor ablation can act as an in situ vaccine whose systemic power ...