Starving Tumors on a Chip: Glucose and Oxygen Steer Cancer Growth
A microfluidic 3D tumor model reveals that glucose limits proliferation, oxygen shapes architecture, and glutamine is essential for lung cancer ...
Tag: tumor microenvironment
Sliced Tumors Keep Their Immune System Alive, Opening a New Window on Bladder Cancer Drug Testing
Researchers at Lund University have shown that precision-cut slices of bladder tumors keep their immune cells alive and functional for ...
Molecular Tags of Cell Death: How E3 Ubiquitin Ligases Steer Necroptosis in Cancer
A new review explains how E3 ubiquitin ligases attach molecular tags to the necroptosis machinery, shaping both cancer development and ...
Low Oxygen Turns Inflammatory Switch That Drives Oral Cancer Growth
New research in the British Journal of Cancer shows that oxygen-starved oral cancer cells activate an HMGB1-driven NLRP3 inflammasome pathway ...
How Chronic Stress Feeds Liver Cancer: A Brain-Liver Loop Revealed in Mice
Researchers at Sun Yat-sen University have mapped a hypothalamic vagal circuit through which chronic stress raises acetylcholine in liver tumors, ...
Grid-Shaped Radiation Beats Conventional Beams in Boosting CAR T Therapy for Brain Lymphoma
A rat study shows that spatially fractionated minibeam radiation, unlike conventional radiotherapy, preserves the efficacy of CD19-directed CAR T cells ...
Melanoma’s Deadly Shift: DNA Methylation Rewrites the Tumor as It Spreads
A paired-sample study of 38 melanoma patients reveals that metastases undergo coordinated DNA methylation reprogramming largely independent of driver mutations, ...
Tumors Are Not Sterile: How Microbes Living Inside Cancers Reshape Immunity and Immunotherapy
A new review in Molecular Cancer argues that microbes living inside tumors dynamically reprogram immunity and can determine whether patients ...
Aging Fibroblasts Fuel Ovarian Cancer Growth Through a Single Secreted Protein
New research shows that senescent cancer-associated fibroblasts in high-grade serous ovarian cancer secrete Tenascin-C, which activates SDC4-ERK signaling in tumor ...
Mathematical Model Points to Ways of Rewiring Tumors for Stronger Cancer Drug Delivery
A mechanistic model from Mass General Brigham and the University of Cyprus shows how normalizing the tumor microenvironment, without over-tightening ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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