Tag: tumor microenvironment

An exploratory analysis of a randomized trial in locally advanced rectal cancer found that an IL1B gene variant was linked ...

Cancer’s Master Switch: New Map Reveals How Tumors Outsmart Immunotherapy

A sweeping new review in Molecular Cancer maps the PD-1/PD-L1 axis from immune evasion mechanisms to next-generation therapeutics, offering a ...

SRPX2 Emerges as a Master Switch Behind Colorectal Cancer Spread and Immune Evasion

New research identifies the secreted protein SRPX2 as a molecular switch that stabilizes the TGF-beta receptor to drive metastasis and ...

Zinc Peroxide-Coated Gold Nanorods Turn Tumors From Cold to Hot by Fusing Photothermal Heat, Chemodynamic Radical Attack, and Metal Ion Immune Signaling

Researchers have engineered a zinc peroxide-coated gold nanorod that combines photothermal heating, self-supplied chemodynamic radicals, and zinc-driven cGAS-STING immune activation ...

AI Model Links Calcium Pump Gene ATP2A2 to Immune Evasion in Lung Cancer

by Juliet Wilcox

A machine learning analysis of inflammation and metabolism genes across seven lung adenocarcinoma cohorts identifies the calcium pump gene ATP2A2 ...

Bacteria Hiding Inside Tumors May Shape Epstein-Barr Virus Activity in Nasopharyngeal Cancer

A paired biopsy study finds that nasopharyngeal carcinoma tissue harbors distinct bacterial communities linked to Epstein-Barr virus activity and immune ...

Scientists Map the Cellular Ecosystem That Drives Liver Cancer Spread Through Blood Vessels

Single-cell RNA sequencing of hepatocellular carcinoma reveals that MRC1-positive macrophages, endothelial capillarization, and strengthened PTPRM signaling define the tumor ecosystem ...

Rewiring the Tumor Engine: How Metabolism Could Become Cancer’s Next Weak Spot

New research highlights microRNAs, mitochondrial ribosomal proteins and lactate signaling as promising targets against cancer's metabolic reprogramming.

How the Bone Marrow Niche Shields Acute Myeloid Leukemia From Chemotherapy