New Benchmark REACH Exposes How Rare Cancer Cell Detection Methods Collapse Under Pressure
A new reproducible benchmark called REACH evaluates ten computational methods for detecting rare malignant cells in single-cell RNA sequencing data, ...
Tag: tumor microenvironment
Persister cells hiding in minimal residual disease drive cancer relapse
A new review outlines how drug-tolerant persister cells hidden within minimal residual disease drive cancer relapse and how pathway inhibitors, ...
Cancer’s Metabolic Battleground: How Immunometabolism Became Immunotherapy’s Next Frontier
A systematic bibliometric review of more than 3,200 publications reveals that tumor immunometabolism research has surged since 2020, shifting from ...
Protease Inhibitors May Finally Crack Cancer’s Drug Resistance Problem
A new review argues that proteases drive chemoresistance through drug transport, matrix remodeling, and cell death signaling, and that precision-targeted ...
Personalized Cancer Spheroids Bring Tumor Reality Into the Lab
A new review highlights how patient-derived 3D cancer spheroids could transform precision oncology by recreating tumor architecture, drug resistance, and ...
AI Reads the Whole Lung to Predict Which Cancer Patients Will Benefit From Immunotherapy
Researchers developed a whole-lung radiomics AI model that predicts which lung cancer patients will achieve complete pathological response to neoadjuvant ...
Ovarian Cancer Cells Depend on USP15 Enzyme, Offering a Sharper Therapeutic Target
UMBC researchers found that ovarian cancer cells depend heavily on the enzyme USP15, and reducing it slows tumor growth, disrupts ...
Lactate-Driven Epigenetic Shifts Reshape Liver Cancer Immunity
New research reveals that lactate-driven histone lactylation promotes Treg/Th17 imbalance in liver cancer via the PTPRM-STAT3 axis.
Nerve Signal Neuromedin U Shields Aggressive Prostate Cancer From Immune Attack
Wistar Institute researchers found that the neurotransmitter neuromedin U suppresses T cell infiltration at the earliest stage of neuroendocrine prostate ...
How Stroke Injury Feeds the Brain’s Deadliest Tumors
A new Nature Cancer study shows that stroke remodels the brain's tumor microenvironment, creating tumor-associated astrocytes and macrophages that drive ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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