Three microRNAs reveal breast cancer resistance patterns
A review finds that miR-125b, miR-375 and miR-451 are linked to breast cancer chemoresistance through distinct, context-dependent mechanisms that require ...
Tag: tumor microenvironment
Single-Cell Sequencing Extends Tumor Analysis to Fixed Clinical Samples
A Roche-led benchmark found that the 10X Genomics GEM-X Flex assay with chop-fix processing improves single-cell RNA profiling of frozen ...
Single-cell map reveals lncRNA networks shaping cancer outcomes
A pan-cancer single-cell framework identifies 667 cell-specific long noncoding RNAs and thousands of functional pairs linked to tumor heterogeneity and ...
Spatial epigenomics reveals stromal niche-associated regulatory programs across pancreatic neuroendocrine tumor grades
A combined single-nucleus and spatial ATAC-seq study maps grade-associated chromatin regulatory programs in non-functional pancreatic neuroendocrine tumors, revealing spatially organized ...
New Study Identifies UBA1 as a Key Biomarker in Multiple Myeloma
A new study identifies UBA1 as a primary candidate biomarker for multiple myeloma by integrating ubiquitination and liquid-liquid phase separation ...
AI Model SPACER Decodes the Hidden Rules of Cell Recruitment in Human Tissue
An interpretable deep learning model called SPACER reads spatial transcriptomics data to reveal the molecular and spatial rules that govern ...
Tumor Stiffness on Ultrasound Reveals Hidden Aggressive Cells in Thyroid Cancer
A new study shows that the maximum stiffness value from shear wave elastography can non-invasively reveal cancer-associated fibroblast activation in ...
Silent Interferon Signals May Flag Ovarian Tumors That Shrug Off Chemotherapy
A cautious reanalysis of single-cell, TCGA, MRI, and cell-line data links muted type-I interferon signaling and altered cell-state programs to ...
MiR-145 emerges as a driver and biomarker of the fibrotic tumor microenvironment
A new study identifies miR-145 as a driver and biomarker of the fibrotic tumor microenvironment, linking NOTCH signaling, promoter hypomethylation, ...
Turning liver tumor ablation into a vaccine: the immune logic behind a new HCC strategy
A new review explains how tumor ablation triggers a transient immune response in liver cancer and why combining it with ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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