AI Model Borrows From Lookalike Cells to Predict How Tumors Respond to Drugs
A new graph neural network framework called DrugSAGE predicts cancer drug responses by aggregating transcriptomic features from tumors and their ...
Tag: Transcriptomics
Gene Network Rewiring Reveals Hidden Drug Response Clues in Colorectal Cancer Organoids
Researchers in Japan used organoid-line-specific regulatory network analysis on patient-derived colorectal cancer organoids to uncover drug-response-associated subnetworks that conventional biomarkers ...
Single Regulatory Protein Supercharges Hydrogen Production in Deep-Sea Archaeon
Overexpressing the regulatory protein EnfR in the hydrogen-producing archaeon Thermococcus onnurineus NA1 boosts formate-dependent growth and hydrogen output by rebalancing ...
Algal Bloom Toxins Inflame Livers and Scramble Fat Metabolism in Endangered Chinese Fish
A multi-omics study shows that Microcystis aeruginosa exudates and the sphingolipid phytosphingosine drive hepatic inflammation, oxidative stress and lipid metabolic ...
Fungal Allies Decoded: How Trichoderma Rewires Melon Roots to Defeat Fusarium Wilt
A new transcriptomic study reveals how Trichoderma asperellum and T. gamsii reprogram melon root defense genes and suppress Fusarium pathogen ...
High-Altitude Holsteins Reveal a Hidden RNA Code Behind Hypoxia Tolerance
A new transcriptomic study of Holstein cows reveals thousands of messenger and long non-coding RNAs shifting with altitude, pointing to ...
Retracted Review Explored How Fish Genes Could Reshape Sustainable Aquaculture Feeds
A retracted Blue Biotechnology review traced how nutrigenomics, from RNA sequencing to CRISPR, could tailor fish diets to their genes ...
Glycolysis Gene PGAM2 Emerges as Key Driver of Bull Fertility and Testis Size
A multi-omics study of Blcattle Black bulls identifies the glycolytic enzyme PGAM2 as a central hub linking energy metabolism, testicular ...
How Silicon Helps a Hardy Millet Beat Salt Stress at the Gene Level
A transcriptomic study reveals how silicon supplementation reprograms antioxidant defense, carbon metabolism and hormone biosynthesis to help finger millet tolerate ...
Hidden RNA Errors Found at the Synapse in Frontotemporal Dementia
Multi-omic profiling of synaptosomes from C9ORF72-frontotemporal dementia brain and patient-derived neurons reveals widespread synaptic molecular disruption and, for the first ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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