Stem Cell Exosomes Carrying a Circular RNA May Worsen Rheumatoid Arthritis, Study Finds
A new study reports that exosomes released by inflamed synovial stem cells carry the circular RNA circRNF20, which worsens rheumatoid ...
Tag: TLR4
Bacterial Toxin Challenge Gets a Timing Makeover in the Hunt for Brain-Saving Plant Compounds
A new review proposes a kinetics- and mechanism-informed framework for using lipopolysaccharide-induced neuroinflammation models to screen phytochemicals with greater rigour ...
Cannabis-Derived Enzyme Blocker Shields Kidneys From Deadly Sepsis Damage in Rat Study
A new rat study shows that the FAAH inhibitor URB597 protects kidneys from sepsis-associated injury by suppressing inflammation, apoptosis, and ...
Vascular Receptor TLR4 Emerges as a Master Switch Between Vascular Aging and Targeted Senotherapeutics
A new review in Aging Cell positions endothelial TLR4 as a context-dependent molecular rheostat controlling vascular senescence, arguing that precision ...
Immune Enzyme PTPN2 Emerges as Master Switch in Sepsis Inflammation
McGill University researchers have identified the enzyme PTPN2 as a key regulator of non-canonical inflammasome activation, revealing how it shapes ...
Clam Immunity Decoded: Mannose Receptor RpMR1 Shields Manila Clams From Deadly Vibrio Infection
Researchers at Dalian Ocean University have identified a mannose receptor gene family in the Manila clam and shown that its ...
Liver Protein Fetuin-A Drives Glucagon Release, New Study Finds
New research shows that the liver-derived protein Fetuin-A stimulates glucagon synthesis and secretion through inflammatory TLR4 signaling and interference with ...
Designed Protein Blocks Inflammation Receptor at Its Membrane Core
Scripps Research scientists used computer-aided protein design to create a synthetic transmembrane protein that binds TLR4 inside the cell membrane ...
Ancient Chinese Herbal Medicine May Tame Chemotherapy’s Toxic Toll by Reshaping the Gut Microbiome
A new review synthesizes molecular and clinical evidence that traditional Chinese medicine can ease chemotherapy-induced toxicities in gastric cancer by ...
Heat Stress Rewires Gut Microbes to Fuel Inflammation, and Arginine May Dampen the Fire
A new Microbiome study shows heat stress disrupts gut microbes to raise LPS and deplete arginine, amplifying MyD88-driven inflammation, and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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