SGK1 inhibition eases fibrosis in experimental bronchiolitis obliterans
SGK1 inhibition reduced fibrosis and airway obstruction in a mouse bronchiolitis obliterans model and suppressed fibrosis-related molecular changes in human ...
Tag: TGF-β1
Cell study finds IL-1β amplifies TGF-β1 effects in SK-Hep1 cells through p38 MAPK-linked SMAD2/3 signaling
An in vitro SK-Hep1 cell study found that IL-1β enhanced TGF-β1-induced fibronectin and N-cadherin expression, migration and invasion through a ...
One Receptor, Two Fates: β3-Adrenoceptor Drives Fibrosis in Cardiac Fibroblasts via β-Arrestin2
A new study shows that β3-adrenergic receptor activation drives profibrotic signaling in cardiac fibroblasts through β-arrestin2 and the JNK/c-Jun pathway, ...
Stressed immune cells may help liver cancer invade blood vessels, study finds
Researchers have identified a stress-responsive subset of MAIT cells that promotes an immunosuppressive peritumoral environment and microvascular invasion in hepatocellular ...
Single-Cell Atlas Reveals How the Metabolic Enzyme PDK4 Drives Scarring After Heart Attack
A single-cell atlas of nearly a quarter-million cardiac fibroblasts reveals eight distinct cell populations and identifies the metabolic enzyme PDK4 ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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