Immune Repertoire Aging Accelerates After 50, Shaped by Sex, CMV and Cancer
A large multi-cohort analysis shows that T cell receptor repertoire diversity declines in an accelerated, nonlinear fashion after age 50, ...
Tag: TCGA
Three-Gene Signature Tied to Tumor Purity Predicts Survival in Pancreatic Cancer
A three-gene signature linked to tumor purity stratifies pancreatic adenocarcinoma patients by survival and reveals differences in CD8-positive T-cell activation.
NLRC4 Acts as a Non‐Canonical Tumour Suppressor in Lung Adenocarcinoma by Inhibiting PI3K/AKT/mTOR Signalling to Induce Protective Autophagy
A new study shows that the immune sensor NLRC4 acts as a tumour suppressor in lung adenocarcinoma by restoring PTEN ...
Saliva Proteins LCN2 and MMP9 Show Biomarker Promise in Head and Neck Cancer
A prospective case–control study of 351 HNSCC patients finds that salivary and serum levels of LCN2, MMP9 and the LCN2/MMP9 ...
Men live longer on enfortumab vedotin than women, retrospective analysis finds
A retrospective international analysis found male metastatic urothelial carcinoma patients survived longer on enfortumab vedotin than females, with higher NECTIN-4 ...
Rheumatism drug teriflunomide shows subtype-dependent effects in breast cancer cells
A cell study finds teriflunomide suppresses growth signalling in luminal breast cancer cells while triple-negative cells show adaptive kinase rewiring.
PCGF1 Drives Glioma Cell Growth by Raising Levels of CCDC34
A study combining database analyses, glioma tissue samples, and cell-line experiments reports that PCGF1 upregulates CCDC34, which is associated with ...
RNF152 Tags PD-L1 for Destruction and Curbs Immune Evasion in Kidney Cancer
A study in Medical Oncology reports that the E3 ubiquitin ligase RNF152 is low in clear cell renal cell carcinoma, ...
MicroRNA miR-183-3p emerges as candidate regulator of ESR1 in colorectal cancer
An integrative analysis combining sequencing, Mendelian randomization, tissue cohorts and a luciferase assay identifies miR-183-3p as a candidate ESR1 3′-UTR-binding ...
Lactylation gene signature predicts outcomes in clear cell renal cell carcinoma
A machine-learning 15-gene lactylation signature predicts prognosis and drug response in clear cell renal cell carcinoma, with CCNA2 identified as ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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