Cellular Bubbles and Molecular Trash Tags: A New Route for Antibody Drugs Into the Brain
University of Ottawa researchers report that extracellular vesicles can ferry engineered antibodies across the blood-brain barrier, and that tagging disease ...
Tag: tau
Scientists Date Alzheimer Plaques in Living Human Brain for the First Time
Researchers have for the first time captured and chemically dated Alzheimer disease pathology in living human brain tissue, revealing rapid ...
RNA-Binding Protein HuR Emerges as a Master Switch in Tau Splicing and Alzheimer’s Genes
A new study identifies the RNA-binding protein HuR as a repressor of tau exon 10 splicing and a regulator of ...
Stress-Tagged Ubiquitin Emerges as a Molecular Beacon for Toxic Tau in Alzheimer’s Disease
Mayo Clinic researchers report that ubiquitin phosphorylated at serine 65 is covalently attached to a soluble, oligomeric tau population in ...
Scientists Receive Up to $51.7 Million to Predict Protein Misfolding Before Disease Begins
A co-led Buck Institute and Georgetown University team has won an ARPA-H award of up to $51.7 million to predict ...
Succulent Plant Extract Shows Promise Against Alzheimer’s in Fruit Fly Model
A methanol extract of the West African medicinal plant Caralluma dalzielii improved survival, behaviour, antioxidant defences, and tau-related gene expression ...
Mutant Tau Pushes the Cell’s Protein Factory into Overdrive, Study Finds
New research in Translational Psychiatry shows that disease-associated MAPT mutations drive tau accumulation in the nucleolus, hyperactivating ribosomal DNA transcription ...
Sleepless and Stressed: Insomnia May Unlock Stress Link to Alzheimer’s Amyloid Buildup
A Swedish study of memory clinic patients finds that lifetime stress exposure is linked to brain amyloid accumulation only in ...
The Golgi Apparatus Emerges as a Hidden Driver of Alzheimer’s Disease
A new review argues that the long-overlooked Golgi apparatus, supported by human genetic, proteomic, and lipidomic evidence, may be a ...
Dementia May Not Be a Brain Disease at All, NIH Scientists Argue
NIH researchers argue that dementia may be the late-life manifestation of a systemic failure of energy regulation rather than a ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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