Targeting CD74 Macrophages Relieves Osteoarthritis in Mice
A new preclinical study identifies CD74-expressing macrophages as a target for osteoarthritis treatment in mice using lipid nanoparticles.
Tag: synovium
Synovial Stress Genes Track Local Joint Inflammation Rather Than Osteoarthritis Stage
A comprehensive multi-cohort transcriptomic analysis reveals that synovial NRF2-HO-1-GPX4 axis remodeling in knee osteoarthritis is biologically heterogeneous and primarily driven ...
Study Links Synovial Protein Misfolding to Osteoarthritis Inflammation
A new study in Arthritis Research & Therapy links protein misfolding in the synovium to the severity of osteoarthritis inflammation, ...
Piezo1 Mechanosensor Emerges as a Hub Linking Load and Inflammation in Knee Osteoarthritis
A new review synthesizes evidence that the mechanosensitive channel Piezo1 links abnormal joint loading to inflammatory and catabolic signaling across ...
Hip fat pad may hold key to stem cell therapy for osteoarthritis
A new review argues that the hip's cotyloid fossa fat pad is a promising but still uncharacterized source of therapeutic ...
Mitochondrial Dysfunction Emerges as a Shared Network Behind Osteoarthritis Pain
A review proposes that mitochondrial dysfunction across cartilage, synovium, subchondral bone and neural compartments forms a shared pathological network linking ...
Immune Cells in Knee Joints Show Lipid-Driven Inflammation, Study Finds
A new single-cell study identifies the enzyme LTA4H in inflammatory myeloid cells as a link between lipid metabolism and knee ...
Practical Toolbox Enables Improved In Vitro Fibrosis Modelling
Fibrosis is one of medicine’s most persistent and difficult biological problems: a repair response that refuses to switch off. Across ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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