The Fibroblast Problem: Why Liver Cancer Drugs So Often Fail
A new review identifies three fibroblast-driven mechanisms that make liver cancer cells resistant to kinase inhibitors and immunotherapy, while warning ...
Tag: SPP1
Alveolar Stem Cells Cross the Lung’s Divide to Rebuild Damaged Airways
A Nature study shows that alveolar type 2 stem cells migrate across compartmental boundaries and, guided by immune-derived SPP1 and ...
SPP1 emerges as a master switch shaping the tumor immune landscape
A new review details how the matrix protein SPP1 orchestrates immunosuppression across the tumor microenvironment and outlines emerging strategies to ...
Single-Cell Atlas Reveals Macrophages That May Drive Chronic Kidney Transplant Rejection
A single-cell multi-omic study of transplanted mouse kidneys identifies SPP1-positive macrophages and a CEBPβ-centered regulatory program as candidate drivers of ...
Glial Cells Turn Against Gut Neurons in Hirschsprung Disease, Study Finds
A new study shows that the redox enzyme TXNRD1 drives enteric glial cells into a pathological SPP1-high state that suppresses ...
Macrophage Gene Signatures Predict Colorectal Cancer Prognosis, Machine Learning Study Finds
By integrating bulk and single-cell RNA sequencing with machine learning, researchers in China have identified a nine-gene macrophage signature that ...
Tumor Vesicles Loaded with SPP1 Rewire Fibroblasts to Shield Lung Cancer from Immunity
New research shows that lung adenocarcinoma cells package the protein SPP1 into extracellular vesicles to reprogram fibroblasts into an MMP11-positive ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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