Macrophage Signal WNT5A Drives Lung Cancer Scarring That Blocks Immunotherapy
A new study reveals how SPP1-positive macrophages secrete WNT5A to activate matrix-remodeling fibroblasts in lung adenocarcinoma, building a stiff tumor ...
Tag: SPP1 macrophages
Hidden Immune Saboteurs: Scientists Map the Cells That Shield Colorectal Tumors
By combining spatial and single-cell transcriptomics, researchers have mapped previously unknown immunosuppressive niches in colorectal cancer, including SPP1-positive macrophage rings ...
Cholesterol-Hungry Immune Cells May Decide Survival in Head and Neck Cancer
A multi-omics study finds that LDL cholesterol metabolism reshapes macrophages and tumor cells in head and neck squamous cell carcinoma, ...
Obesity Quietly Rewrites the Cellular Landscape of Colorectal Cancer Before Tumors Form
A dual-platform spatial transcriptomics study reveals that obesity reshapes colorectal cancer in two phases, first reprogramming healthy gut epithelium and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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